10252-82-1

Basic information

• Product Name: 4-(MORPHOLINE-4-SULFONYL)-BENZOIC ACID
• Synonyms: benzoic acid, 4-(4-morpholinylsulfonyl)-;4-morpholinosulfonylbenzoic acid;p-(Morpholinosulfonyl)benzoic acid
• CAS NO: 10252-82-1
• Molecular Formula: C₁₁H₁₃NO₅S
• Molecular Weight: 271.29
• Mol File: 10252-82-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 483.3°C at 760 mmHg
• Flash Point: 246.1°C
• Appearance: /
• Vapor Pressure: 3.75E-10mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-(MORPHOLINE-4-SULFONYL)-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(MORPHOLINE-4-SULFONYL)-BENZOIC ACID(10252-82-1)
• EPA Substance Registry System: 4-(MORPHOLINE-4-SULFONYL)-BENZOIC ACID(10252-82-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 10252-82-1(Hazardous Substances Data)

Usage

General Description

4-(Morpholine-4-sulfonyl)-benzoic acid is a chemical compound with the molecular formula C13H13NO5S. It is synthesized by the reaction of 4-aminobenzoic acid with morpholine-4-sulfonyl chloride. 4-(MORPHOLINE-4-SULFONYL)-BENZOIC ACID is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has been shown to exhibit antibacterial and antifungal properties, making it a potential candidate for the development of new drugs to combat microbial infections. Additionally, 4-(morpholine-4-sulfonyl)-benzoic acid has been studied for its potential use as a corrosion inhibitor in industrial applications.

InChI:InChI=1/C11H13NO5S/c13-11(14)9-1-3-10(4-2-9)18(15,16)12-5-7-17-8-6-12/h1-4H,5-8H2,(H,13,14)/p-1

Upstream product

• 332413-01-1 4-(morpholine-4-sulfonyl)benzoic acid methyl ester 
• 110-91-8 morpholine 
• 10130-89-9 p-carboxyphenylsulfonyl chloride 

Downstream Products

• 332413-01-1 4-(morpholine-4-sulfonyl)benzoic acid methyl ester 
• 1423715-35-8 (E)-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-4-(morpholinosulfonyl)benzohydrazide 
• 333787-98-7 4-(morpholinosulfonyl)benzohydrazide 
• 654682-86-7 4-(morpholine-4-sulfonyl)-benzoyl chloride 

Relevant articles and documents

Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis

A series of thiophene-benzenesulfonamide derivatives was designed and synthesized by exploring the structure-activity relationship of lead compounds 2,3-disubstituted thiophenes 25a and 297F as antituberculosis agents, which displayed potent antimycobacterial activity against drug-susceptible and clinically isolated drug-resistant tuberculosis. In particular, compound 17b, which had improved activity (minimum inhibitory concentration of 0.023 μg/mL) compared with the lead compounds, displayed good intracellular antimycobacterial activity in macrophages with a reduction of 1.29 log10 CFU. A druggability evaluation indicated that compound 17b had favorable hepatocyte stability, low cytotoxicity, and low hERG channel inhibition. Moreover, compound 17b exhibited modest in vivo efficacy in an acute mouse model of tuberculosis. In addition, the molecular docking study elucidated the binding mode of compound 17b in the active site of DprE1. Therefore, compound 17b may be a promising antituberculosis lead for further research.

COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY

The present invention relates to compounds of formula (I) and their uses. In particular, though not exclusively, it concerns heterocyclic compounds that inhibit the biogenesis of adhesive pili in Gram- negative bacteria, and their use in the prevention or

HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES

The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the