10252-82-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-(Morpholine-4-sulfonyl)-benzoic acid is utilized as a building block in the synthesis of pharmaceuticals and agrochemicals, playing a crucial role in the development of new drugs and chemical products. Its versatile chemical structure allows for the creation of a wide range of compounds with potential therapeutic and pesticidal properties.
Used in Antibacterial and Antifungal Applications:
4-(MORPHOLINE-4-SULFONYL)-BENZOIC ACID is employed as an antibacterial and antifungal agent due to its demonstrated properties against various microbial strains. Its ability to combat infections makes it a promising candidate for the development of new drugs to address the growing issue of antibiotic resistance and fungal infections.
Used in Corrosion Inhibition:
4-(Morpholine-4-sulfonyl)-benzoic acid has been studied for its potential use as a corrosion inhibitor in industrial applications. Its capacity to protect materials from corrosion could be valuable in various industries, including manufacturing, construction, and automotive, where metal protection is essential for durability and safety.

InChI:InChI=1/C11H13NO5S/c13-11(14)9-1-3-10(4-2-9)18(15,16)12-5-7-17-8-6-12/h1-4H,5-8H2,(H,13,14)/p-1

Upstream product

• 110-91-8 morpholine 
• 10130-89-9 p-carboxyphenylsulfonyl chloride 
• 332413-01-1 4-(morpholine-4-sulfonyl)benzoic acid methyl ester 

Downstream Products

• 332413-01-1 4-(morpholine-4-sulfonyl)benzoic acid methyl ester 
• 1423715-35-8 (E)-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-4-(morpholinosulfonyl)benzohydrazide 
• 333787-98-7 4-(morpholinosulfonyl)benzohydrazide 
• 654682-86-7 4-(morpholine-4-sulfonyl)-benzoyl chloride 

Relevant academic research and scientific papers

Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis

A series of thiophene-benzenesulfonamide derivatives was designed and synthesized by exploring the structure-activity relationship of lead compounds 2,3-disubstituted thiophenes 25a and 297F as antituberculosis agents, which displayed potent antimycobacterial activity against drug-susceptible and clinically isolated drug-resistant tuberculosis. In particular, compound 17b, which had improved activity (minimum inhibitory concentration of 0.023 μg/mL) compared with the lead compounds, displayed good intracellular antimycobacterial activity in macrophages with a reduction of 1.29 log10 CFU. A druggability evaluation indicated that compound 17b had favorable hepatocyte stability, low cytotoxicity, and low hERG channel inhibition. Moreover, compound 17b exhibited modest in vivo efficacy in an acute mouse model of tuberculosis. In addition, the molecular docking study elucidated the binding mode of compound 17b in the active site of DprE1. Therefore, compound 17b may be a promising antituberculosis lead for further research.

Diaryl 2- amide-substituted thiophene imide ester compound as well as preparation method and application thereof (by machine translation)

The invention also discloses a 2 - synthesis method thereof, and an application of the compound as an antibacterial agent, in the phthisis-caused by the bacterium, in particular to the, mycobacterium-induced infectious disease (especially (Tuberculosis,TB), mycobacterium- induced mycobacterium, tuberculosis), and (I) the invention, specifically relates to a pharmaceutical composition containing the compound of the present invention or, a R pharmaceutical composition comprising the compound of the present invention. 1 , R2 , R3 , R4 , R5 As described Y in the present invention. as described in the specification, the present invention is directed, to the preparation of novel compounds, having an anti-mycobacterial activity as potential, new drug (s) for the treatment (TB) or preventative treatment of infectious diseases, consisting of M. tuberculosis, in particular phthisis- caused by tubercular mycobacteria, while being useful in overcoming the problems associated with drug resistance. (by machine translation)

COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY

The present invention relates to compounds of formula (I) and their uses. In particular, though not exclusively, it concerns heterocyclic compounds that inhibit the biogenesis of adhesive pili in Gram- negative bacteria, and their use in the prevention or

PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING

The invention provides novel inhibitors of hedgehog signaling that are useful as s therapeutic agent for treating malignancies where the compounds have the general formula (I): where A, X, Y R1, R2, R3, R4, m and n are as described herein.

HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES

The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the

Pyridyl inhibitors of hedgehog signalling

The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

CHEMICAL COMPOUNDS

Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11betaHSD1 are described

Benzothiazole derivatives with activity as adenosine receptor ligands

The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.

Orally-active elastase inhibitors

This invention relates to novel morpholinourea and related derivatives of pentafluoroethyl peptides which are orally active elastase inhibitors. These compounds are useful in the treatment of various inflammatory diseases and emphysema.