102520-97-8

Basic information

• Product Name: N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97
• Synonyms: N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97;1,1-Dimethylethyl (2-hydroxy-1,1-dimethylethyl)carbamate, 2-Hydroxy-1,1-dimethylethyl)carbamic acid 1,1-dimethylethyl ester, (2-Hydroxy-1,1-dimethylethyl)carbamic acid tert-butyl ester;tert-Butyl (1-hydroxy-2-Methylpropan-2-yl)carbaMate;N-Boc-2-aMino-2-Methylpropan-1-ol;N-Boc-2-aMino-2-Methyl-1-propanol 97%;Carbamic acid,N-(2-hydroxy-1,1-dimethylethyl)-, 1,1-dimethylethyl ester;tert-Butyl N-(2-hydroxy-1,1-dimethylethyl)carbamate;tert-Butyl (1-hydroxy-2-methylpropan-2-yl)
• CAS NO: 102520-97-8
• Molecular Formula: C₉H₁₉NO₃
• Molecular Weight: 189.253
• Mol File: 102520-97-8.mol
• Article Data: 56

Chemical Properties

• Melting Point: 57-62 °C
• Boiling Point: 286.543°C at 760 mmHg
• Flash Point: 127.097°C
• Appearance: /
• Density: 1.012g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.453
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 12.24±0.46(Predicted)
• CAS DataBase Reference: N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97(102520-97-8)
• EPA Substance Registry System: N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97(102520-97-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• Hazardous Substances Data: 102520-97-8(Hazardous Substances Data)

Usage

Uses

tert-Butyl (1-Hydroxy-2-methylpropan-2-yl)carbamate is used in preparation of diamine derivatives as KCa3.1 potassium channel inhibitors.

InChI:InChI=1/C9H19NO3/c1-8(2,3)13-7(12)10-9(4,5)6-11/h11H,6H2,1-5H3,(H,10,12)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 30992-29-1 Boc-Aib-OH 
• 87413-09-0 Dess-Martin periodane 
• 34619-03-9 tert-butyldicarbonate 
• 500143-63-5 di(tert-butyl) 2-{[tert-butyl(diphenyl)silyl]oxy}-1,1-dimethylethylimidodicarbonate 
• 84758-55-4 N-(tert-butoxycarbonyl)-α-methylalanine methyl ester 

Downstream Products

• 454248-55-6 3-(tert-butyloxycarbonyl)-4,4-dimethyl-[1,2,3]-oxathiazolidine-2,2-dioxide 
• 320581-09-7 (2-amino-1,1-dimethyl-ethyl)-carbamic acid tert-butyl ester 
• 27646-80-6 N-Methyl-2-amino-2-methyl-1-propanol 
• 134597-95-8 tert-butyl (2-methyl-1-(methylamino)propan-2-yl)carbamate 

Relevant articles and documents

N-Alkyl-5,5-dimethyl-2-oxomorpholin-3-yl radicals. Characterization and reaction with molecular oxygen

The synthesis of bi(4,5,5-trimethyl-2-oxomorpholin-3-yl) (TM-3′ dimer), bi(5,5-dimethyl-4-cthyl-2-oxomorpholin-3-yl) (DEM-3 dimer), and bi(5,5-dimethyl-4-isopropyl-2-oxomorpholin-3-yl) (DIM-3 dimer) by one-electron oxidation of 4,5,5-trimethyl-2-oxomorpholine (8), 5,5-dimethyl-4-ethyl-2-oxomorpholine (9), and 5,5-dimethyl-4-isopropyl-2-oxomorpholine (10), respectively, with photochemically generated rert-butoxyl radical is described. dl-TM-3′ dimer, meso-DEM-3 dimer, and meso-DIM-3 dimer were characterized from spectra and by X-ray crystallography. In solution the radical dimers existed in equilibrium with the captodatively substituted radicals, 4,5,5-trimethyl-2-oxomorpholin-3-yl (TM-3′), 5,5-dimethyl-4-ethyl-2-oxomorpholin-3-yl (DEM-3), and 5,5-dimethyl-4-isopropyl-2-oxomorpholin-3-yl (DIM-3), respectively, as indicated by EPR spectroscopy. The activation parameters for bond homolysis in ethanol solvent were measured by oxidatively trapping the radicals with diphenylpicrylhydrazyl (DPPH). The half-lives for bond homolysis vary by S orders of magnitude at 25°C with a value of only 2.3 s for DIM-3 dimer. DIM-3 dimer reacted quantitatively with molecular oxygen to form a mixture of meso- and dl-bis(5,5-dimethyl-4-isopropyl-2-oxomorpholin-3-yl) peroxides (DIM-3 peroxides), which were isolated and characterized spectroscopically and analytically. At ambient temperature the peroxides fragmented by C-O bond homolysis to release the DIM-3 radical as indicated by EPR spectroscopy and were solvolyzed by protic solvent with release of hydrogen peroxide. The solvolysis was reversed by evaporation of the protic solvent, which restored most of the DIM-3 peroxides. The peroxides also slowly fragmented irreversibly to 5,5-dimethyl-3-hydroxy-4-isopropyl-2-oxomorpholine (21) and 5,5-dimethyl-2,3-dioxo-4-isopropylmorpholine (23) in polar aprotic solvent.

New methods for the preparation of 2-amino-2-methylpropanesulfonic acid

2-Amino-2-methylpropanesulfonic acid 3 was prepared either from 2-N-[(1,1-dimethylethoxy)carbonyl]amino-2-methyl-1-propanol 4 or from 1-N-[(1,1-dimethylethoxy)carbonyl]amino-2-methyl-2-propanol 5 in good overall yields.

Vinyl Sulfone-Based Inhibitors of Nonstructural Protein 2 Block the Replication of Venezuelan Equine Encephalitis Virus

Emerging infectious diseases like those caused by arboviruses such as Venezuelan equine encephalitis virus (VEEV) pose a serious threat to public health systems. Development of medical countermeasures against emerging infectious diseases are of utmost importance. In this work, an acrylate and vinyl sulfone-based chemical series was investigated as promising starting scaffolds against VEEV and as inhibitors of the cysteine protease domain of VEEV's nonstructural protein 2 (nsP2). Primary screen and dose response studies were performed to evaluate the potency and cytotoxicity of the compounds. The results provide structural insights into a new class of potent nonpeptidic covalent inhibitors of nsP2 cysteine protease represented by compound 11 (VEEV TrD, EC50= 2.4 μM (HeLa), 1.6 μM (Vero E6)). These results may facilitate the evolution of the compounds into selective and broad-spectrum anti-alphaviral drug leads.

Ultrasound promoted environmentally benign, highly efficient, and chemoselective N-tert-butyloxycarbonylation of amines by reusable sulfated polyborate

The sulfated polyborate catalyzed an efficient and chemoselective N-tert-butyloxycarbonylation of amines under ultrasonic irradiation is developed. A broad substrate scope has been demonstrated for N-Boc protection of various primary/secondary amines. It allows converting several aliphatic/aryl/heteroaryl amines, amino alcohol, aminoester, and chiral amines to their N-Boc-protected derivatives under solvent-free conditions with excellent yields. The protocol has several advantages such as easy catalyst, and product isolation, short reaction time, excellent yields, outstanding chemoselectivity, and catalyst recyclability, among others. This makes the process practicable, economical, and environmentally benign.

Substituted chiral diaryl macrocyclic compound as TRK inhibitors

The invention relates to a substituted chiral diaryl macrocyclic compound as a TRK inhibitor, and belongs to the technical field. The structure of the chiral diaryl macrocyclic compound is shown as a general formula (I), and the chiral diaryl macrocyclic

NOVEL TRITERPENE DERIVATIVES AS HIV INHIBITORS

The present invention relates to novel triterpene derivatives of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and ring are as defined herein. The invention also relates to novel triterpene derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.