102522-48-5

Basic information

• Product Name: N-[2-Hydroxy-1,1-bis(hydroxyMethyl)ethyl]carbaMic Acid Benzyl Ester
• Synonyms: N-[2-Hydroxy-1,1-bis(hydroxyMethyl)ethyl]carbaMic Acid Benzyl Ester;[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]carbamic acid phenylmethyl ester;Carbamic acid, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-, phenylmethyl ester
• CAS NO: 102522-48-5
• Molecular Formula: C₁₂H₁₇NO₅
• Molecular Weight: 255.26708
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 102522-48-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Acetone, Dichloromethane
• CAS DataBase Reference: N-[2-Hydroxy-1,1-bis(hydroxyMethyl)ethyl]carbaMic Acid Benzyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-Hydroxy-1,1-bis(hydroxyMethyl)ethyl]carbaMic Acid Benzyl Ester(102522-48-5)
• EPA Substance Registry System: N-[2-Hydroxy-1,1-bis(hydroxyMethyl)ethyl]carbaMic Acid Benzyl Ester(102522-48-5)

Safety Data

• Hazardous Substances Data: 102522-48-5(Hazardous Substances Data)

Usage

Chemical Properties

Off-white Solid

Uses

N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]carbamic Acid Benzyl Ester is an intermediate used in the preparation of glycocluster peptides.

Upstream product

• 1125824-87-4 C₁₉H₂₁NO₅ 
• 501-53-1 benzyl chloroformate 
• 77-86-1 2-amino-2-hydroxymethyl-1,3-propanediol 

Downstream Products

• 1228151-32-3 C₅₄H₅₃NO₁₁ 
• 69661-83-2 bis(ferrocenylmethyl)ether 
• 873070-03-2 N-Cbz-bis(hydroxymethyl)(ferrocene-methylene-oxymethyl)aminomethane 
• 873070-04-3 N-Cbz-bis(ferrocene-methylene-oxymethyl)-(hydroxymethyl)aminomethane 
• 151753-73-0 Acetic acid (2R,3S,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-[2-acetoxymethyl-2-benzyloxycarbonylamino-3-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-propoxy]-tetrahydro-pyran-4-yl ester 
• 151734-50-8 2-(benzyloxycarbonylamino)-3-hydroxy-2-(hydroxymethyl)propyl acetate 
• 420107-88-6 N-(benzyloxycarbonyl)-N'-heptadecylcarbamoyloxymethylbis[O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)hydroxymethyl]aminomethane 
• 420107-87-5 N-(benzyloxycarbonyl)-N'-undecylcarbamoyloxymethylbis[O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranozyl)hydroxymethyl]aminomethane 
• 420107-83-1 5-N-(benzyloxycarbonyl)amino-5-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethyl-2,2-dimethyl-1,3-dioxane 
• 420107-86-4 N-(benzyloxycarbonyl)-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethylbis(hydroxymethyl)aminomethane 
• 420107-82-0 5-N-(benzyloxycarbonyl)amino-5-N'-heptadecylcarbamoyloxymethyl-2,2-dimethyl-1,3-dioxane 
• 420107-85-3 N-(benzyloxycarbonyl)-N'-heptadecylcarbamoyloxymethylbis(hydroxymethyl)aminomethane 
• 420107-84-2 N-(benzyloxycarbonyl)-N'-undecylcarbamoyloxymethylbis(hydroxymethyl)aminomethane 

Relevant articles and documents

A METHOD FOR THE PREPARATION OF FINGOLIMOD

The invention relates to a method of preparation of 2-amino-2-[2-(4-octylphenyl)- ethyl]propane-1,3-diol (I), comprising opening of the aziridine ring of the intermediates (LVI) by the treatment with organometallic compounds, preferably the Grignard reage

Truly catalytic and chemoselective cleavage of benzylidene acetal with phosphomolybdic acid supported on silica gel

Phosphomolybdic acid supported on silica gel provides a truly catalytic method for the chemoselective cleavage of benzylidene acetals having sensitive functional groups under mild conditions. It is easy to perform on large scale owing to minimal catalyst loading (0.5 mol-%). Several sensitive functional groups such as TBDPS ether, -OMs, -OAc, allyl ether, N-Boc, N-Fmoc and N-Cbz are stable under the reaction conditions. In addition, benzylidene acetal is selectively cleaved in the presence of isopropylidene ketal. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

SYNTHESIS OF ORGANOMETALLIC MOLECULES THAT CAN BE USED AS MARKERS OF ORGANIC SUBSTANCES

The present invention concerns compounds of general formula (I). These products are preferably used as labels of biomolecules (for example: nucleic acids, oligonucleotides, PNAs, peptides, proteins, steroids etc.) mainly used in the field of diagnostics.