10254-11-2

Basic information

• Product Name: N-(diphenylmethyl)-2-methylbenzamide
• Synonyms: N-(diphenylmethyl)-2-methylbenzamide
• CAS NO: 10254-11-2
• Molecular Formula: C₂₁H₁₉NO
• Molecular Weight: 301.38166
• Mol File: 10254-11-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(diphenylmethyl)-2-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(diphenylmethyl)-2-methylbenzamide(10254-11-2)
• EPA Substance Registry System: N-(diphenylmethyl)-2-methylbenzamide(10254-11-2)

Safety Data

• Hazardous Substances Data: 10254-11-2(Hazardous Substances Data)

Upstream product

• 5448-38-4 N-benzyl-2-methylbenzamide 
• 101-81-5 Diphenylmethane 
• 527-85-5 o-Methylbenzamid 
• 118-90-1 ortho-methylbenzoic acid 
• 933-88-0 ortho-toluoyl chloride 
• 91-00-9 Benzhydrylamine 
• 1612225-91-8 N-(tert-butylperoxy(phenyl)methyl)-2-methylbenzamide 
• 100-58-3 phenylmagnesium bromide 
• 91-01-0 1,1-Diphenylmethanol 
• 529-19-1 2-Methylbenzonitrile 

Relevant articles and documents

Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2

Inhibition of coronavirus (CoV)-encoded papain-like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure-activity relationships (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS-CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PLpro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS-CoV-2 replication in cell culture suggesting that, due to the high structural similarities of the target proteases, inhibitors identified against SARS-CoV PLpro are valuable starting points for the development of new pan-coronaviral inhibitors.

A facile access for the C-N bond formation by transition metal-free oxidative coupling of benzylic C-H bonds and amides

Using 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as the oxidant, we communicate an efficient oxidative C-N coupling of benzylic C-H bonds with amides to afford a series of amination products in good yields. A wide range of functional groups as well as various sulfonamides and carboxamides are well tolerated. Moreover, this reaction involves both the challenging C-H functionalization and C-N bond formation.

HClO4-SiO2 as an efficient and recyclable catalyst for the synthesis of amide derivatives

An efficient and clean procedure for amide alkylation is reported by direct condensation of equimolar amounts of benzylic and allylic alcohols with primary amides in the presence of silica perchloric acid (HClO4-SiO 2). The direct co