1025423-97-5

Basic information

• Product Name: 1-[2-(4-chlorophenyl)ethyl]-3-[(3,4-dihydroxyphenyl)methyl]-3-methylthiourea
• Synonyms: 1-[2-(4-chlorophenyl)ethyl]-3-[(3,4-dihydroxyphenyl)methyl]-3-methylthiourea
• CAS NO: 1025423-97-5
• Molecular Weight: 350.869
• Mol File: 1025423-97-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-[2-(4-chlorophenyl)ethyl]-3-[(3,4-dihydroxyphenyl)methyl]-3-methylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(4-chlorophenyl)ethyl]-3-[(3,4-dihydroxyphenyl)methyl]-3-methylthiourea(1025423-97-5)
• EPA Substance Registry System: 1-[2-(4-chlorophenyl)ethyl]-3-[(3,4-dihydroxyphenyl)methyl]-3-methylthiourea(1025423-97-5)

Safety Data

• Hazardous Substances Data: 1025423-97-5(Hazardous Substances Data)

Upstream product

• 156-41-2 4-chlorophenylethylamine 
• 17608-10-5 2-(4-chlorophenyl)ethyl isothiocyanate 
• 125789-62-0 4-methylaminomethyl-pyrocatechol 
• 1025423-95-3 4-[(methylamino)methyl]benzene-1,2-diol hydrobromide 

Relevant articles and documents

Synthesis and SAR of novel capsazepine analogs with significant anti-cancer effects in multiple cancer types

We previously demonstrated that capsazepine (CPZ), a synthetic transient receptor potential Vanilloid subtype 1 (TRPV1) antagonist, has significant anti-cancer effects in vivo. The purpose of this study was to develop more potent analogs based upon CPZ pharmacophore and structure–activity relationships (SAR) across analogs. We generated 30 novel compounds and screened for their anti-proliferative effects in cultured HeLa cervical cancer cells. Cell viability assays identified multiple compounds with IC50s 50 50s of 1–2.5 μM in HSC-3and PC-3cells. Thus, we propose that these novel CPZ analogs may serve as efficacious therapeutic agents against multiple tumor types that warrant further development for clinical application.