1025700-72-4

Upstream product

• 1025700-46-2 5-bromo-4-isopropyl-thiazole 
• 1025699-99-3 3-(5-methyl-pyridin-2-yl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester 
• 1025700-04-2 3-iodo-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester 

Downstream Products

• 1025700-73-5 3-(5-isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid 

Relevant academic research and scientific papers

THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is a group of formula A or formula B, and X, R2, R3, R4, R5, R6, Ra and Rb are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.

THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES

Compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 is a group of formula A or formula B; and X, R2, R3, R4, R5, R6, Ra and Rb are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.