102574-40-3Relevant academic research and scientific papers
Regio- and Stereoselective Diarylation of 1,3-Dienes via Ni/Cr Cocatalysis
Chen, Qing-An,Hu, Yan-Cheng,Ji, Ding-Wei,Li, Ying,Zhang, Wei-Song,Zhang, Xiang-Xin,Zhao, Chao-Yang
, p. 2158 - 2165 (2022/02/14)
Through the formation of the thermodynamically favored Cr(III)-O bond, the Nozaki-Hiyama-Kishi reaction has been widely applied in the functionalization of carbonyl compounds with the help of Ni catalysis. Herein, a divergent regio- and stereoselective diarylation of dienes has been developed under Ni/Cr cocatalysis without the inherent driving force for the formation of polar metal alkoxides. Preliminary experimental studies have been conducted to elucidate the key roles of Ni, Cr, and redox-active bis(imino)pyridine (PDI) ligands. The proposed mechanism suggests that the newly formed C-C bond of this diarylation was created by organonickel species instead of organochromium species.
Total Syntheses of Malabaricones B and C via a Cross-Metathesis Strategy
Kundu, Kshama,Nayak, Sandip K.
, p. 1776 - 1782 (2017/06/28)
The malabaricones A-D belong to the class of diarylnonanoids isolated from the Myristicaceae family of plants. Although malabaricone C displayed various interesting biological activities, its isolation remains tedious due to its close chemical similarity to malabaricones A, B, and D. Therefore, development of an efficient synthesis route has become essential to cater to the need of large amounts of malabaricone C for its pharmacological profiling. So far there is only one report of the synthesis of malabaricone C through a lengthy sequence of reactions. We have developed an efficient and short route for the syntheses of malabaricones B and C, which will also provide a convenient access to all other members of the malabaricone family. Synthesis of an important building block, -aryl heptyl bromide, employed in the synthesis was realized by adopting a cross-metathesis reaction as the key step.
The attempted stereoselective synthesis of chiral 2,2′-biindoline
Gresser, Mary J.,Wales, Steven M.,Keller, Paul A.
experimental part, p. 6965 - 6976 (2010/09/18)
The attempted first stereoselective synthesis of 2,2′-biindoline using a metathesis-Sharpless asymmetric dihydroxylation strategy results in the synthesis of the heterocycle in poor to modest stereoselectivity. Attempts to improve the ee by varying the he
