10258-29-4Relevant articles and documents
Chemical modifications of natural triterpenes-glycyrrhetinic and boswellic acids: evaluation of their biological activity
Subba Rao,Kondaiah, Paturu,Singh, Sanjay K.,Ravanan, Palaniyandi,Sporn, Michael B.
, p. 11541 - 11548 (2008)
Synthetic analogues of naturally occurring triterpenoids; glycyrrhetinic acid, arjunolic acid, and boswellic acids, by modification of A-ring with a cyano- and enone-functionality, have been reported. A novel method of synthesis of α-cyanoenones from isoxazoles is reported. Bioassays using primary mouse macrophages and tumor cell lines indicate potent anti-inflammatory and cytotoxic activities associated with cyano-enones of boswellic acid and glycyrrhetinic acid.