1025812-75-2Relevant academic research and scientific papers
Preparation and Application of Amino Phosphine Ligands Bearing Spiro[indane-1,2′-pyrrolidine] Backbone
Feng, Lifei,Jiao, Peng,Li, Hongjie,Li, Shasha,Zhang, Jinxia
, p. 9460 - 9473 (2019/08/26)
P,Nsp3-bidentate chiral ligands bearing spiro[indane-1,2′-pyrrolidine] backbone were prepared in gram scale for the first time. Pd complexes of these air-stable amino phosphine ligands could catalyze asymmetric allylic substitutions of malonate-, alcohol-, and amine-type nucleophiles in up to 97percent ee and 99percent yield. A crystal structure of [Pd(II)(η3-1,3-diphenylallyl)(ligand)]PF6 indicated possible transition states of the catalytic reactions. These ligands are characteristic of a very rigid backbone, which is simple but highly effective. They rival C2-symmetric bisphosphine, P,Nsp2-bidentate, and P,Nsp3-bidentate ligands in tested allylic substitutions. ?
A stereoselective concise synthesis of C2- and meso-aminodiols from (R)-phenylglycinol
Scialdone, Mark A.,Meyers
, p. 7533 - 7536 (2007/10/02)
Oxazolidines derived from (R)-phenylglycinol can undergo diastereoselective vinyl- and aryl addition to give, after oxidative cleavage, meso- and C2-diethanol amines.
