102582-93-4 Usage
Description
4-(Trifluoromethylthio)phenylacetic acid is a chemical compound that is widely used in the field of organic synthesis due to its reactive nature. This molecule is characterized by the presence of both the trifluoromethylthio and the phenylacetic acid groups, which confer unique properties to the compound. The trifluoromethylthio group is known for its high stability and bioactivity amplification, making it a valuable component in pharmaceuticals. It enhances the metabolic stability of bioactive molecules and improves their pharmacokinetic parameters. Additionally, this group is resistant to chemical transformations, which is beneficial in chemical synthesis. The phenylacetic acid group contributes to the compound's acidity and provides an aromatic ring structure that serves as a platform for further chemical reactions. Overall, 4-(Trifluoromethylthio)phenylacetic acid is an essential tool in both pharmaceuticals and organic chemistry.
Uses
Used in Pharmaceutical Industry:
4-(Trifluoromethylthio)phenylacetic acid is used as a building block for the synthesis of various pharmaceutical compounds. Its trifluoromethylthio group enhances the metabolic stability and bioactivity of the resulting molecules, while the phenylacetic acid group provides a platform for further chemical reactions, making it suitable for the development of new drugs.
Used in Organic Chemistry:
4-(Trifluoromethylthio)phenylacetic acid is used as a reagent in various organic synthesis reactions. Its reactive nature allows for the formation of new chemical bonds and the creation of diverse molecular structures. The presence of the trifluoromethylthio and phenylacetic acid groups makes it a versatile compound for use in the synthesis of complex organic molecules.
Used in Chemical Synthesis:
4-(Trifluoromethylthio)phenylacetic acid is used as a key intermediate in the synthesis of various chemical compounds. Its stability and resistance to chemical transformations make it a reliable component in the production of a wide range of chemical products. The phenylacetic acid group also offers opportunities for further modification and functionalization, expanding the potential applications of the synthesized compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 102582-93-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,5,8 and 2 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 102582-93:
(8*1)+(7*0)+(6*2)+(5*5)+(4*8)+(3*2)+(2*9)+(1*3)=104
104 % 10 = 4
So 102582-93-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H7F3O2S/c10-9(11,12)15-7-3-1-6(2-4-7)5-8(13)14/h1-4H,5H2,(H,13,14)
102582-93-4Relevant articles and documents
FMS-LIKE TYROSINE KINASE INHIBITORS
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Page/Page column 25; 29; 53, (2020/03/31)
The present invention relates to Fms-like tyrosine kinase (FLT3) inhibitors. The present invention provides novel 4-quinolinone derivatives used as FLT3 inhibitors and for treatment and/or prevention of tumors.
Metallation reactions XXII. Regioselective metallation of (trifluoromethyl) (alkylthio) benzenes
Cabiddu,Cabiddu,Cadoni,Corrias,Fattuoni,Floris,Melis
, p. 125 - 140 (2007/10/03)
The metallation reactions of (trifluoromethyl)(alkylthio)benzenes with organolithium reagents and with the butyllithium/potassium tert-butoxide superbasic mixture are here described. The results, according to the theoretical calculations of energy minima, show the monometallation regiochemistry is directed by the sulphur atom. On the other side, the bimetallation, that can be performed only on methylthio derivatives, depends on the organometallic reagent employed. Using butyllithium the stronger coordinative power of sulphur prevails and products metallated in ortho and alpha positions to this atom are mainly formed. With the more basic sec-butyllithium and with the Superbase, because of mutual competition between the thioalkyl and trifluoromethyl groups, mixtures of products, coming from metallation in the ortho position to the trifluoromethyl group and in the alpha position of the thiomethylic group, are obtained. In addition, products coming from substitution ortho,alpha to the thiomethyl group are also formed. All mono- and bimetallated intermediates showed to be good synthons for the synthesis of fluoro- and (trifluoromethyl)-substituted benzothiophenes and (trifluoromethyl)benzenes substituted on the thioalkylic chain and/or on the ring.
