1025849-08-4Relevant academic research and scientific papers
Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists
Riechers, Hartmut,Albrecht, Hans-Peter,Amberg, Willi,Baumann, Ernst,Bernard, Harald,B?hm, Hans-Joachim,Klinge, Dagmar,Kling, Andreas,Müller, Stefan,Raschack, Manfred,Unger, Liliane,Walker, Nigel,Wernet, Wolfgang
, p. 2123 - 2128 (2007/10/03)
A novel class of endothelin-A receptor ligands was discovered by high-throughput screening. Lead structure optimization led to highly potent antagonists which can be synthesized in a short sequence. The compounds are endothelin-A-selective, are orally available, and show a long duration of action.
