178306-47-3

Basic information

• Product Name: Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester
• Synonyms: Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester;2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid methyl ester;Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate;α-Hydroxy-β-Methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester;Ambrisentan PI-4;ALST-01;2-hydroxy-3-methoxy-3;3-diphenylpropanoic acid methyl ester
• CAS NO: 178306-47-3
• Molecular Formula: C₁₇H₁₈O₄
• Molecular Weight: 286.32
• EINECS: 1806241-263-5
• Product Categories: Drug Intermediates;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 178306-47-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 440.722 °C at 760 mmHg
• Flash Point: 159.393 °C
• Appearance: /
• Density: 1.176
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly)
• PKA: 12.37±0.20(Predicted)
• CAS DataBase Reference: Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester(178306-47-3)
• EPA Substance Registry System: Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester(178306-47-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 178306-47-3(Hazardous Substances Data)

Usage

Uses

Ambrisentan intermediate.

InChI:InChI=1/C17H18O4/c1-20-16(19)15(18)17(21-2,13-9-5-3-6-10-13)14-11-7-4-8-12-14/h3-12,15,18H,1-2H3

Upstream product

• 67-56-1 methanol 
• 76527-25-8 3,3-diphenyloxirane-2-carboxylic acid methyl ester 
• 119-61-9 benzophenone 
• 96-34-4 methyl chloroacetate 
• 178306-51-9 (S)-2-hydroxy-3-methoxy-3,3-diphenyl propionic acid 
• 178306-52-0 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid 

Downstream Products

• 1025933-19-0 3-Methoxy-2-(4-methyl-pyrimidin-2-yloxy)-3,3-diphenyl-propionic acid methyl ester 
• 1240470-84-1 (S)-methyl-2-(4,6-dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate 
• 178306-52-0 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid 
• 177036-78-1 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester 
• 177036-94-1 ambrisentan 
• 171714-84-4 darusentan 
• 1106685-61-3 (S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid methyl ester 
• 177036-79-2 (S)-methyl 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate 
• 1231755-36-4 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid tertiary butylamine salt 
• 1431363-04-0 methyl 3-methoxy-2-oxo-3,3-diphenylpropionate 
• 177036-94-1 ambrisentan 
• 178306-45-1 (S)-methyl-2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate 
• 178306-46-2 (.S)-2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenyl propionic acid 
• 213774-07-3 methyl 3,3-dicyclohexyl-2-hydroxy-3-methoxypropionate 

Relevant articles and documents

LC-MS/MS characterization of forced degradation products of ambrisentan: Development and validation of a stability-indicating RP-HPLC method

The current study reports the characterization of degradation products of ambrisentan by liquid chromatography-tandem mass spectrometry, and development and validation of a stability-indicating reversed phase high performance liquid chromatographic method

An improved method of preparing Anritsu tezosentan

The invention belongs to the field of chemical synthesis, and discloses an improved method used for preparing ambrisentan. According to the improved method, 2-hydroxy-3-methoxy-3,3-diphenylpropionic ester and 4,6-dimethyl-2-methylsulfonylpyrimidine are su

METHOD FOR PRODUCING (S)-2-HYDROXYPROPANOIC ACID DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method for producing an (S)-2-hydroxypropanoic acid derivative and ambrisentan having high optical purity in an industrially advantageous manner. SOLUTION: There is provided a method for producing an (S)-2-hydroxypropanoic acid derivative represented by the formula (1a) by reacting an (RS)-2-hydroxypropanoic acid derivative represented by the formula (1) with (S)-(+)-1,2,3,4-tetrahydro-1-naphthylamine to form a diastereomer salt, followed by desalting. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT