1025875-29-9

Upstream product

• 1026054-16-9 (6-nitrobenzo[d][1,3]dioxol-5-yl)(3,4,5-trimethoxyphenyl)methanol 
• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 
• 712-97-0 6-nitro-1,3-benzodioxole-5-carbaldehyde 

Downstream Products

• 109502-44-5 (6-aminobenzo[d][1,3]dioxol-5-yl)(3,4,5-trimethoxyphenyl)methanone 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of combretabenzodiazepines: A novel class of anti-tubulin agents

In the present manuscript, starting from the 1,4-benzodiazepin-2-one nucleus, a privileged structure in medicinal chemistry, we have synthesized a novel class of cis-locked combretastatins named combreatabenzodiazepines. They show similar cytotoxic and antitubulin activity compared to combretastatin A-4 in neuroblastoma cells, showing a better pharmacokinetic profile. This class of compounds has therefore the potential for further development as antitubulin agents.

Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents

A new type of inhibitor of tubulin polymerization was discovered on the basis of the combretastatin molecular skeleton. The lead compounds in this series, compounds 6 and 7, strongly inhibited tubulin polymerization in vitro and significantly arrested cel