1025930-06-6

Upstream product

• 130387-74-5 4-fluorophenylmagnesium chloride 
• 60176-77-4 (1S,4R)-4-hydroxy-2-cyclopentenyl acetate 
• 913715-42-1 (1R,4R)-4-(4-fluorophenyl)-cyclopent-2-enol 

Downstream Products

• 1026489-45-1 (2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-pentane-1,5-diol 
• 1027908-81-1 tert-Butyl-[(2R,3R)-3-(4-fluoro-phenyl)-5-iodo-2-iodomethyl-pentyloxy]-dimethyl-silane 
• 201855-60-9 (3S,4R)-[1-benzyl-4-piperidin-3-yl-4-(4-fluorophenyl)]methanol 

Relevant academic research and scientific papers

Concise synthesis of trans- and cis-3,4-disubstituted piperidines based on regio- and stereoselective allylation of cyclopentenyl esters

3,4-Disubstituted piperidines were synthesized through anti S N2′ allylation of 4-substituted 2-cyclopentenyl esters with reagents based on RMgX and CuX, thus allowing equal access to both trans- and cis-isomers. As an application, the paroxeti