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201855-60-9

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  • 201855-60-9 Structure

  • Basic information

    1. Product Name: trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol
    2. Synonyms: (-)-(3S,4R)-4-(4-Fluorophenyl)-1-(phenylmethyl)-3-piperidinemethanol;(-)-trans-1-Benzyl-4-(4-fluorophenyl)-3-hydroxymethylpiperidine;(3S,4R)-4-(4-Fluorophenyl)-1-(phenylmethyl)- 3-piperidinemethanol;trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol;Paroxetine Anhydrous EP Impurity H
    3. CAS NO:201855-60-9
    4. Molecular Formula: C19H22FNO
    5. Molecular Weight: 299.38
    6. EINECS: N/A
    7. Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 201855-60-9.mol
    9. Article Data: 10

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 402.1°C at 760 mmHg
    3. Flash Point: 197°C
    4. Appearance: /
    5. Density: 1.139g/cm3
    6. Vapor Pressure: 3.45E-07mmHg at 25°C
    7. Refractive Index: 1.571
    8. Storage Temp.: -20°C, Inert atmosphere
    9. Solubility: Chloroform (Slightly), DMSO (Slightly)
    10. CAS DataBase Reference: trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol(CAS DataBase Reference)
    11. NIST Chemistry Reference: trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol(201855-60-9)
    12. EPA Substance Registry System: trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol(201855-60-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 201855-60-9(Hazardous Substances Data)

201855-60-9 Usage

Chemical Properties

Colorless Thick Oil

Uses

Paroxetine intermediate

Check Digit Verification of cas no

The CAS Registry Mumber 201855-60-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,8,5 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 201855-60:
(8*2)+(7*0)+(6*1)+(5*8)+(4*5)+(3*5)+(2*6)+(1*0)=109
109 % 10 = 9
So 201855-60-9 is a valid CAS Registry Number.
InChI:InChI=1/C19H22FNO/c20-18-8-6-16(7-9-18)19-10-11-21(13-17(19)14-22)12-15-4-2-1-3-5-15/h1-9,17,19,22H,10-14H2/t17-,19-/m0/s1

201855-60-9 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0000581)  Paroxetine hydrochloride (anhydrous) impurity H  European Pharmacopoeia (EP) Reference Standard

  • 201855-60-9

  • Y0000581

  • 1,880.19CNY

  • Detail

201855-60-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol

1.2 Other means of identification

Product number -
Other names [(3S,4R)-1-Benzyl-4-(4-fluorophenyl)piperidin-3-yl]methanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:201855-60-9 SDS

201855-60-9Relevant articles and documents

Multigram-scale flow synthesis of the chiral key intermediate of (-)-paroxetine enabled by solvent-free heterogeneous organocatalysis

?tv?s, Sándor B.,Pericàs, Miquel A.,Kappe, C. Oliver

, p. 11141 - 11146 (2019/12/28)

The catalytic enantioselective synthesis of the chiral key intermediate of the antidepressant (-)-paroxetine is demonstrated as a continuous flow process on multi-gram scale. The critical step is a solvent-free organocatalytic conjugate addition followed

Optically pure γ-butyrolactones and epoxy esters via two stereocentered HKR of 3-substituted epoxy esters: A formal synthesis of (-)-paroxetine, Ro 67-8867 and (+)-eldanolide

Devalankar, Dattatray A.,Karabal, Pratibha U.,Sudalai, Arumugam

supporting information, p. 1280 - 1285 (2013/05/08)

The HKR of racemic anti- or syn-3-substituted epoxy esters catalyzed by a Co(iii)salen complex provides ready access to the corresponding enantioenriched 3,4-disubstituted γ-butyrolactones and 3-substituted epoxy esters. This strategy has been successfully employed in the formal synthesis of biologically active 3,4-disubstituted piperidine derivatives, (-)-paroxetine and Ro 67-8867 and a natural product, (+)-eldanolide.

Stereospecific construction of substituted piperidines. Synthesis of (-)-paroxetine and (+)-laccarin

Bower, John F.,Riis-Johannessen, Thomas,Szeto, Peter,Whitehead, Andrew J.,Gallagher, Timothy

, p. 728 - 730 (2007/10/03)

Short and efficient enantioselective syntheses of (-)-paroxetine and (+)-laccarin are described based on the highly stereospecific cleavage of C(3)-substituted 1,3-cyclic sulfamidates. The Royal Society of Chemistry.

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