1026-36-4

Usage

Uses

Used in Pharmaceutical Synthesis:
2,4-Diamino-6-phenylpteridine hydrochloride is used as a key intermediate in the synthesis of pharmaceuticals for its unique structural properties that facilitate the creation of new drug molecules.
Used in Dye Production:
2,4-Diamino-6-phenylpteridine hydrochloride is utilized as a precursor in the production of dyes, capitalizing on its chemical composition to yield a range of colorants for various applications.
Used in the Production of Folate Analogs:
2,4-Diamino-6-phenylpteridine hydrochloride is used as an important intermediate in the manufacturing of folate analogs, which are essential in treating medical conditions such as cancer and bacterial infections, due to its role in the development of these therapeutic agents.
Used in Organic Chemistry Research:
2,4-Diamino-6-phenylpteridine hydrochloride serves as a valuable component in organic chemistry, contributing to the advancement of research and development of new chemical reactions and processes.
Used in Materials Science:
2,4-Diamino-6-phenylpteridine hydrochloride is employed in materials science for its potential to contribute to the development of new materials with unique properties, making it a versatile compound in this field.

Upstream product

• 532-54-7 oxo-phenyl-acetaldehyde oxime 
• 39944-62-2 2,4,5,6-tetraamino-pyrimidine dihydrochloride 
• 1422390-73-5 4-amino-2-(N,N-dimethylaminomethyleneamino)-6-(phenyl)pterin 
• 396-01-0 triamterene 

Relevant academic research and scientific papers

Voltammetry of the pteridine derivative, triamterene

Triamterene, 6-phenyl-2,4,7-triaminopteridine (1), a diuretic, gave two steps of two-electron reduction waves on Tast polarography (TP). The first step was ascribed to the reversible reduction of 1 into unreducible 5,8- dihydrotriamterene (2) by cyclic voltammetry (CV). Tautomerization of 2 to reducible 7,8-dihydrotriamterene (3) was rapid first-order reaction catalyzed by acid and base. The second step was attributed to the irreversible reduction of 3 into 5,6,7,8-tetrahydrotriamterene (4), which was oxidized to 2,4-diamino-6-phenylpteridine at a more positive potential than those of 2 and 3 into 1 on CV. The oxidation of 3 to 1 was observed at a more positive potential than that of 2 to 1 on CV. The anodic wave of 1 on TP in alkaline solution was ascribed to formation of the mercury complex of 1.

Negishi coupling of pteridine-o-sulfonates

Negishi coupling of pteridine-O-sulfonate with Zn-aryls is reported. Hydrolysis of the protecting groups with 1MNH3 gave the 6-subustituted 2,4-diaminopteridine while hydrolysis with 1 M NaOH gave the 6-subsituted pterin.

Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: Structure-activity relationship of antagonists of (6R)-5,6,7,8- tetrahydrobiopterin cofactor

The family of nitric oxide synthases (NOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO), an important cellular messenger molecule which has been implicated in the pathophysiology of septic shock and inflammatory and neurode

A new, general and regioselective method for the synthesis of 2,6-disubstituted 4-aminopteridines

A new synthetic method for the preparation of 2,6-disubstituted 4-aminopteridines is described. Treatment of a-substituted 4,5,6-triaminopyrimidines with α-ketoaldoximes in MeOH affords in a regioselective one-step reaction 2,6-disubstituted 4-aminopteridines in high yield.