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532-54-7 Usage


2-Isonitrosoacetophenone is a beige to yellowish crystalline powder that is known for its unique chemical properties and various applications across different industries. It is a compound that has garnered interest due to its potential uses in chemical and pharmaceutical research.


Used in Chemical Analysis:
2-Isonitrosoacetophenone is used as a reagent for the detection of ferrous ions, with which it forms a blue color soluble in chloroform. This property makes it a valuable tool in chemical analysis and research, particularly in the identification and quantification of ferrous ions in various samples.
Used in Pharmaceutical Industry:
2-Isonitrosoacetophenone is used to create complexes with copper and amino acids. These complexes have demonstrated enhanced antimicrobial activities, particularly against gram-positive bacteria, and also possess antioxidant properties. This makes them potentially useful in the development of new antimicrobial agents and therapies, as well as in the field of antioxidant research.

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 2558, 1974 DOI: 10.1021/jo00931a022

Purification Methods

Crystallise it from water. [Beilstein 7 IV 2132.]

Check Digit Verification of cas no

The CAS Registry Mumber 532-54-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 532-54:
57 % 10 = 7
So 532-54-7 is a valid CAS Registry Number.

532-54-7 Well-known Company Product Price

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  • CAS number
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  • Alfa Aesar

  • (L02098)  Isonitrosoacetophenone, 97%   

  • 532-54-7

  • 10g

  • 648.0CNY

  • Detail
  • Alfa Aesar

  • (L02098)  Isonitrosoacetophenone, 97%   

  • 532-54-7

  • 50g

  • 1556.0CNY

  • Detail
  • Aldrich

  • (I18202)  2-Isonitrosoacetophenone  97%

  • 532-54-7

  • I18202-5G

  • 587.34CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name 2-Isonitrosoacetophenone

1.2 Other means of identification

Product number -
Other names Benzeneacetaldehyde, α-oxo-, aldoxime

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:532-54-7 SDS

532-54-7Relevant articles and documents

Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors

Jin, Fangfang,Hu, Qiyue,Fei, Hongbo,Lv, Hejun,Wang, Shenglan,Gui, Bin,Zhang, Junzhen,Tu, Wangyang,Zhang, Yun,Zhang, Lei,Wan, Hong,Zhang, Limin,Hu, Bin,Yang, Fanglong,Bai, Chang,He, Feng,Zhang, Lianshan,Tao, Weikang

supporting information, p. 195 - 201 (2021/02/06)

In this study, a series of novel hydroxyamidine derivatives were identified as potent and selective IDO1 inhibitors by structure-based drug design. Among them, compounds 13-15 and 18 exhibited favorable enzymatic and cellular activities. Compound 18 showed improved bioavailability in mouse, rat, and dog (F% = 44%, 58.8%, 102.1%, respectively). With reasonable in vivo pharmacokinetic properties, compound 18 was further evaluated in a transgenic MC38 xenograft mouse model. The combination of compound 18 with PD-1 monoclonal antibody showed a synergistic antitumor effect. These data indicated that compound 18 as a potential cancer immunotherapy agent should warrant further investigation.

Arylglyoxal oximes as putative C-nucleophiles in eliminative nucleophilic substitution process

Tsyganov, Dmitry V.,Samet, Alexander V.,Dorovatovskii, Pavel V.,Khrustalev, Victor N.,Semenov, Victor V.

, p. 296 - 298 (2019/06/13)

Reaction of arylglyoxal oximes ArCOCH=NOH (Ar = 4-MeOC6H4, Ph) with 5-arylfurazanopyrazines proceeds as vicarious nucleophilic substitution of hydrogen in pyrazine ring with the elimination of hyponitrous acid, affording 5-(aroylmethylidene)-6-aryl-4H-furazano[3,4-b]pyrazines. Structure of the product was confirmed by X-ray diffraction.

Hydroheteroarylation of Unactivated Alkenes Using N-Methoxyheteroarenium Salts

Ma, Xiaoshen,Dang, Hester,Rose, John A.,Rablen, Paul,Herzon, Seth B.

supporting information, p. 5998 - 6007 (2017/05/04)

We report the first reductive coupling of unactivated alkenes with N-methoxy pyridazinium, imidazolium, quinolinium, and isoquinolinium salts under hydrogen atom transfer (HAT) conditions, and an expanded scope for the coupling of alkenes with N-methoxy pyridinium salts. N-Methoxy pyridazinium, imidazolium, quinolinium, and isoquinolinium salts are accessible in 1-2 steps from the commercial arenes or arene N-oxides (25-99%). N-Methoxy imidazolium salts are accessible in three steps from commercial amines (50-85%). In total 36 discrete methoxyheteroarenium salts bearing electron-donating, electron-withdrawing, alkyl, aryl, halogen, and haloalkyl substituents were prepared (several in multigram quantities) and coupled with 38 different alkenes. The transformations proceed under neutral conditions at ambient temperature, provide monoalkylation products exclusively, and form a single alkene addition regioisomer. Preparatively useful and complementary site selectivities in the addition of secondary and tertiary radicals to pyidinium salts are documented: harder secondary radicals favor C-2 addition (2->10:1), while softer tertiary radicals favor bond formation to C-4 (4.7->29:1). A diene possessing a 1,2-disubstituted and 2,2-disubstituted alkene undergoes hydropyridylation at the latter exclusively (61%) suggesting useful site selectivities can be obtained in polyene substrates. The methoxypyridinium salts can also be employed in dehydrogenative arylation, borono-Minisci, and tandem arylation processes. Mechanistic studies support the involvement of a radical process.

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