1026069-44-2

Basic information

• Product Name: {2-[3-(4-chloro-phenyl)-3-oxo-2-(toluene-4-sulfonyl)-1-p-tolyl-propyl]-4-methyl-phenyl}-carbamic acid tert-butyl ester
• CAS NO: 1026069-44-2
• Molecular Weight: 618.194
• Mol File: 1026069-44-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {2-[3-(4-chloro-phenyl)-3-oxo-2-(toluene-4-sulfonyl)-1-p-tolyl-propyl]-4-methyl-phenyl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {2-[3-(4-chloro-phenyl)-3-oxo-2-(toluene-4-sulfonyl)-1-p-tolyl-propyl]-4-methyl-phenyl}-carbamic acid tert-butyl ester(1026069-44-2)
• EPA Substance Registry System: {2-[3-(4-chloro-phenyl)-3-oxo-2-(toluene-4-sulfonyl)-1-p-tolyl-propyl]-4-methyl-phenyl}-carbamic acid tert-butyl ester(1026069-44-2)

Safety Data

• Hazardous Substances Data: 1026069-44-2(Hazardous Substances Data)

Upstream product

• 14618-59-8 N-(tert-butoxycarbonyl)-4-methylaniline 
• 491616-54-7 1-(4'-chlorophenyl)-3-(4'-methylphenyl)-2-(p-toluenesulfonyl)-2-(E)-propen-1-one 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 106-49-0 p-toluidine 
• 61820-94-8 1-(4-chlorophenyl)-2-tosylethanone 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Synthesis of substituted quinolines using the dianion addition of N-Boc-anilines and α-tolylsulfonyl-α,β-unsaturated ketones

A short and versatile synthesis of substituted quinolines is provided. Alkylation of sodium tolylsulfinate with bromomethyl- or chloromethyl ketones generates β-keto sulfones. Knoevenagel condensation of the β-keto sulfones with an aldehyde provides α-tolylsulfonyl-α,β-unsaturated ketones. Michael addition of the dianion of N-Boc-anilines in the presence of CuCN and LiCl with the unsaturated ketone generates a 1,4-adduct, which after deprotection of the Boc group and thermal elimination of the tolyl sulfone provides the quinoline.