102609-56-3

Upstream product

• 24237-54-5 tinoridine 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 112101-01-6 7-Benzyl-2-phenylamino-5,6,7,8-tetrahydro-pyrido[4',3':4,5]thieno[2,3-d][1,3]thiazin-4-one 
• 105543-96-2 7-Benzyl-2-(2-hydroxy-ethylsulfanyl)-3-phenyl-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one 
• 312513-68-1 7-benzyl-3-phenyl-2-thioxo-2,3,5,6,7,8-hexahydro-1H-pyrido[4',5':4,5]-thieno[2,3-d]-pyrimidin-4-one 
• 893683-63-1 3-amino-2-phenylamino-7-benzyl-5,6,7,8-tetrahydropyrido[4′,3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one 
• 127140-92-5 C₁₇H₁₇N₃OS₂ 
• 519154-11-1 9-benzyl-2,3,4,7,8,9,10,12-octahydro-6H-pyrido[4',3':4,5]thieno[2,3-d]pyrimido[1,2-a]pyrimidin-6-one 
• 300346-37-6 8-benzyl-2,3,6,7,8,9-hexahydro-imidazo[1,2-a]pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-5(11H)-one 
• 105543-95-1 7-Benzyl-2-methylsulfanyl-3-phenyl-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one 
• 105543-97-3 (7-Benzyl-4-oxo-3-phenyl-3,4,5,6,7,8-hexahydro-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-ylsulfanyl)-acetic acid ethyl ester 
• 105543-92-8 2-(2-Amino-ethylsulfanyl)-7-benzyl-3-phenyl-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one 

Relevant academic research and scientific papers

Hyperbolic mixed-type inhibition of acetylcholinesterase by tetracyclic thienopyrimidines

A series of tetracyclic thienopyrimidines (7-14) was prepared and investigated as inhibitors of acetylcholinesterase from Electrophorus electricus acetylcholinesterase (EeAChE), as well as human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE). A new synthetic procedure was employed for the synthesis of the angularly fused heterocycles 7-10. Among them, the presence of a tetrahydropyrido ring with a benzyl rest at the basic nitrogen was required for EeAChE inhibition. A detailed kinetic analysis of the hyperbolic mixed-type inhibition of EeAChE by 9-14 was performed. These heterocyclic compounds inhibited EeAChE with Ki values of less than 3 μM. Most α values were relatively close to 1, indicating a similar affinity of the inhibitor to the free enzyme and the enzyme-substrate complex. Inhibitor 10 displayed a rather uncompetitive pattern of inhibition (α=0.47) and a relatively high residual activity of a postulated ternary enzyme-substrate- inhibitor complex (β=0.24).

Synthesis, characterization and biological studies of some novel thieno[2,3-d]pyrimidines

Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2-aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolothienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using

Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition

A series of thieno[1,3]oxazin-4-ones and thieno[1,3]thiazin-4-ones were synthesized and investigated as inhibitors of the α/β hydrolases cholesterol esterase (CEase) and acetylcholinesterase (AChE). The introduction of a cycloaliphatic five- or six-member

The Facile Synthesis of 2-Aminothienothiazin-4-ones, in Some Cases 5,6-Anelated

The cyclization of ethyl 2-thioureidothiophene-3-carboxylates is known to give 2-thioxothienopyrimidin-4-ones not only under basic conditions but also upon treatment with ethanolic hydrochloric acid.On the other hand, we have found that ethyl 2-thi