1026147-45-4Relevant academic research and scientific papers
Synthesis, antibacterial and antifungal activities of 2,5-disubstituted-1, 3,4-oxadiazoles
Nadagouda,Khochage, Atul,Pradeepkumar,Korat, Haresh,Gadaginamath,Joshi
, p. 85 - 90 (2013/12/04)
A series of 2,5- distributed 1,3,4-oxadiazole derivatives were prepared and evaluated for their antibacterial and antifungal activities. 5-[(2, 4, 6-trichlorophenoxy) methyl]- 1,3,4-oxadiazol-2-thiol 5 was synthesized by the reaction of 2-(2,4,6,-trichlorophenoxy) acetic acid hydrazide 4 with CS 2 and KOH in ethanol. The compound 5 on reaction with ethyl chloroacetate gave ethyl-2-(5-(2,4,6-trichlorophenoxy)methyl)-1,3,4-oxadiazol- 2-ylthio) acetate 6 and this on further hydrolysis by sodium hydroxide, followed by acidification gave 2-(5-((2,4,6-trichlorophenoxy)methyl)-1l3,4-oxadiazol-2- ylthio) acetic acid. 7.The compound 5 on condensation with p-benzoquinone in dry acetone gave 2- (5-((2,4l6-trichlorophenoxy)methyl)-1,3l4-oxadiazol-2-ylthio) benzene-1,4-diol 8.1,3,4- Oxadiazole derivatives 9-15 were prepared by treating hydrazide 4 with aromatic acids, in presence of dehydrating agent. Structures of the newly synthesized compounds were confirmed on the basis of physico-chemical and spectral data. All the synthesized compounds were screened for their antibacterial and antifungal activities using broth micro dilution method. Compounds have shown moderate to good antibacterial and antifungal activities.
Synthesis of some 1,3,4-oxadiazole derivatives as potential anti-inflammatory agents
Amir, Mohd,Javed,Kumar, Harish
, p. 1014 - 1019 (2008/09/18)
The synthesis of some new 1,3,4-oxadiazole derivatives and 1,2,4-triazine-5-one has been described. IR, 1H NMR and mass spectral data support the structures of newly synthesized compounds. All the compounds have been tested in vivo for their an
