190588-40-0

Basic information

• Product Name: 2-(2,4,6-trichlorophenoxy)acetic acid hydrazide
• Synonyms: 2-(2,4,6-trichlorophenoxy)acetic acid hydrazide
• CAS NO: 190588-40-0
• Molecular Weight: 269.515
• Mol File: 190588-40-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-(2,4,6-trichlorophenoxy)acetic acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4,6-trichlorophenoxy)acetic acid hydrazide(190588-40-0)
• EPA Substance Registry System: 2-(2,4,6-trichlorophenoxy)acetic acid hydrazide(190588-40-0)

Safety Data

• Hazardous Substances Data: 190588-40-0(Hazardous Substances Data)

Usage

Common uses

Plant growth regulator, inhibits weed growth, promotes growth of desirable crops

Mechanism of action

Disrupts hormone balance in plants, leading to stunted growth and reduced weed competition

Herbicide derivative

2,4,6-trichlorophenoxyacetic acid (2,4,6-T)

Potential concerns

Toxicity, environmental impact, limited and regulated use in some regions

Upstream product

• 643-14-1 3,4,6-trichloro-2-methyl-phenol 
• 105-39-5 chloroacetic acid ethyl ester 
• 88-06-2 2,4,6-Trichlorophenol 
• 575-89-3 2-(2,4,6-trichlorophenoxy)acetic acid 

Downstream Products

• 402939-30-4 2-[5-(2,4,6-trichloro-phenoxymethyl)-[1,3,4]oxadiazol-2-yl]-phenol 
• 1378872-36-6 (E)-N'-((1H-pyrrol-2-yl)methylene)-2-(2,4,6-trichlorophenoxy)acetohydrazide 
• 1026147-50-1 C₂₀H₁₃Cl₃N₂O₂ 
• 1026147-52-3 3-(2,4,6-trichlorophenoxymethyl)-1,2,5,6-tetrahydro-1,2,4-triazin-5-one 
• 1026147-46-5 C₁₇H₁₁Cl₃N₂O₄ 
• 1026147-45-4 C₁₅H₁₀Cl₃N₃O₂ 
• 1026147-48-7 C₂₃H₁₆Cl₃FN₂O₂ 
• 1026147-51-2 C₂₂H₁₄Cl₅N₃O₂ 
• 1026147-49-8 C₂₂H₁₇Cl₃N₂O₃ 
• 1026147-47-6 C₂₁H₂₁Cl₃N₂O₂ 
• 1026147-43-2 C₁₅H₇Cl₅N₂O₂ 
• 1026147-44-3 C₁₆H₉Cl₅N₂O₃ 

Relevant articles and documents

Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment

Developing novel fungicide candidates are intensively promoted by the rapid emergences of resistant fungi that outbreak on agricultural production. Aiming to discovery novel antifungal leads, a series of 1,3,4-oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment were constructed for evaluating their inhibition effects against phytopathogenic fungi in vitro and in vivo. Systematically structural optimizations generated the bioactive molecule I32 that was identified as a promising inhibitor against Rhizoctonia solani with the in vivo preventative effect of 58.63% at 200 μg/mL. The observations that were captured by scanning electron microscopy and transmission electron microscopy demonstrated that the bioactive molecule I32 could induce the sprawling growth of hyphae, the local shrinkage and rupture on hyphal surfaces, the extreme swelling of vacuoles, the striking distortions on cell walls, and the reduction of mitochondria numbers. The above results provided an indispensable complement for the discovery of antifungal lead bearing a quinazolin-4(3H)-one and 1,3,4-oxadiazole fragment.

Synthesis, Nematicidal Activity, and 3D-QSAR of Novel 1,3,4-Oxadiazole/ Thiadiazole Thioether Derivatives

Forty one novel 1,3,4-oxadiazole/thiadiazole thioether derivatives containing phenoxy moiety were designed and synthesized. Bioassay demonstrated that some of them showed remarkable activities against Tylenchulus semipenetrans in vitro and in vivo. Compounds 20, 21, 35 and 39 showed excellent lethal activities after treatment for 48?h in vitro, with LC50 values of 13.4?±?1.8, 11.7?±?2.5, 13.7?±?2.4 and 13.3?±?1.1?mg·L–1, respectively, which were obviously superior to fosthiazate (49.1?±?2.8?mg·L–1) and avermectin (26.6?±?2.3?mg·L–1). Compound 21 can effectively control the citrus nematode disease caused by T. semipenetrans at 200?mg·L–1 in vivo with (68?±?3)% inhibitory effect, which was even better than that of avermectin ((63?±?2)%). The CoMFA and CoMSIA models of three-dimensional quantitative structure-activity relationships (3D-QSARs) were established. The compound 33 was designed based on the 3D-QSAR models with more vigorous nematicidal activities in vitro (LC50?=?9.8?±?1.4?mg·L–1) and in vivo ((70?±?5)%). These results demonstrated that compound 33 can be considered as a potential nematicide.

2,5-substituent-1,3,4-oxadiazole (thiadiazole) thioether derivatives as well as preparation method and application thereof

The invention discloses 2,5-substituent-1,3,4-oxadiazole (thiadiazole) thioether derivatives as well as a preparation method and an application thereof. The 2,5-substituent-1,3,4-oxadiazole (thiadiazole) thioether derivatives have the general formula (I) shown in the following specification, wherein R1 represents as 4-chlorphenyl, 4-fluorophenyl, 4-methylphenyl, 4-methoxyphenyl, 4-nitrophenyl, 4-cyano-3,5-difluorophenyl, 4-trifluoromethylphenyl, 4-trifluoromethoxyphenyl, 4-t-butylphenyl, 2-fluorophenyl and other substituents; R2 represents methyl, ethyl, 4-chlorobenzyl, 2,4-dichlorobenzyl, 4-trifluoromethoxy, benzyl, 4-fluorobenzyl, 4-chlorobenzyl and other substituents; X represents O or S. The compound can be used as a pesticide for killing crop nematode and inhibiting bacterial diseases of crops.