10262-23-4Relevant academic research and scientific papers
Spectral characterization of novel 3-phenyl-2-substituted quinazoline and fused quinazoline derivatives
Mahmoud, Mahmoud R.,Abou-Elmagd, Wael S. I.,Abdelwahab, Salwa S.,Soliman, El-Sayed A.
, p. 1484 - 1490 (2013)
3-phenyl-2-thioxo-quinazolin-4(3H)one 1 was utilized for the construction of some novel 2-substituted quinazolin-4(3H)one derivatives through the formation of 2-hydrazinyl quinazolinone, which was used as the key starting material for the synthesis of 2-heteryl quinazolines via the reaction with one carbon donors, -diketones and -ketoester. Infrared, 1H NMR, and mass spectra of the synthesized compounds were discussed. Some of them showed promising anti-inflammatory activity. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file. Copyright Taylor & Francis Group, LLC.
