10264-27-4

Upstream product

• 108-91-8 cyclohexylamine 
• 142-61-0 Hexanoyl chloride 
• 3173-53-3 Cyclohexyl isocyanate 
• 142-62-1 hexanoic acid 
• 2443-62-1 hexanoic acid hydrazide 
• 2763-78-2 2-cyclohexyl-1-oxa-2-azaspiro[2.5]octane 
• 2051-49-2 n-hexanoic anhydride 
• 106-70-7 methyl hexanoate 
• 123-66-0 Ethyl hexanoate 

Downstream Products

• 4746-28-5 N-hexylcyclohexanamine 
• 30930-83-7 hexanal N-cyclohexylimine 
• 30930-83-7 hexanal cyclohexylimine 

Relevant academic research and scientific papers

N-Acyl-N-(4-chlorophenyl)-4-nitrobenzenesulfonamides: Highly selective and efficient reagents for acylation of amines in water

A variety of N-acyl-N-(4-chlorophenyl)-4-nitrobenzenesulfonamides (1a-e) were synthesized in one pot from 4-chloroaniline under solvent-free conditions and have been developed as chemoselective N-acylation reagents. Selective protection of primary amines in the presence of secondary amines, acylation of aliphatic amines in the presence of aryl amines, and monofunctionalization of primary-secondary diamines as well as selective N-acylation of amino alcohols using these reagents are described. All of the acylation reactions were carried out in water as a green solvent. High stability and easy preparation of these acylating reagents are other advantages of this method.

Recyclable hypervalent iodine(III) reagent iodosodilactone as an efficient coupling reagent for direct esterification, amidation, and peptide coupling

A hypervalent iodine(III) reagent plays a novel role as an efficient coupling reagent to promote the direct condensation between carboxylic acids and alcohols or amines to provide esters, macrocyclic lactones, amides, as well as peptides without racemization. The regeneration of iodosodilactone (1) can also be readily achieved. The intermediate acyloxyphosphonium ion C from the activation of a carboxylic acid is thought to be involved in the present esterification reaction.

Tighter ion pair effect and scale-up study in microwave assisted aminolysis of enolizable esters using potassium tert-butoxide (t-BuOK)

The tighter ion pair effect and scale-up study in aminolysis of enolizable esters using potassium tert-butoxide (t-BuOK) under microwave irradiations is described. This method provides synthetic advantages in terms of reaction time, product yields, eco-friendly environment and scale-up feasibility over the conventional heating method.

A catalyst system for the reaction of carboxylic acids with aliphatic isocyanates

Catalysts have been found for the selective reaction of aliphatic isocyanates with carboxylic acids giving amides after carbon dioxide extrusion. Magnesium and calcium salts lead to a dramatic increase in reaction rates while improving the selectivity when sterically hindered isocyanates and/or carboxylic acids are used.