1026440-10-7Relevant academic research and scientific papers
NOVEL BETULINIC SUBSTITUTED AMIDE DERIVATIVES AS HIV INHIBITORS
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, (2017/02/24)
The present invention relates to novel betulinic substituted amide compounds of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y, Z1, Z2, Z3 and are Formula (II) as defined herein. The invention novel betulinic substituted amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.
Synthesis and SAR of adatanserin: Novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT2 activity as potential anxiolytic and antidepressant agents
Abou-Gharbia, Magid A.,Childers Jr., Wayne E.,Fletcher, Horace,McGaughey, Georgia,Patel, Usha,Webb, Michael B.,Yardley, John,Andree, Terrance,Boast, Carl,Kucharik Jr., Robert J.,Marquis, Karen,Morris, Herman,Scerni, Rosemary,Moyer, John A.
, p. 5077 - 5094 (2007/10/03)
Several novel functionalized adamantyl aryl- and heteroarylpiperazine derivatives were prepared and examined in various receptor binding and behavioral tests to determine their serotonin receptor activities. Many compounds demonstrated modest to high affi
