1026449-85-3

Upstream product

• 100-44-7 benzyl chloride 
• 175988-38-2 1-(3,6-Bis-benzyloxy-2,4-dimethoxy-phenyl)-ethanone 
• 6962-57-8 3,6-dihydroxy-2,4-dimethoxyacetophenone 

Downstream Products

• 175988-59-7 1-(3,6-Dihydroxy-2,4-dimethoxy-phenyl)-2-(4-hydroxy-3-methoxy-phenyl)-3,3-dimethoxy-propan-1-one 
• 135010-74-1 7,3′-dimethoxy-5,6,4′-trihydroxyisoflavone 
• 94390-23-5 5,6,7,4'-tetrahydroxy-3'-methoxyisoflavone 
• 175988-35-9 6-Hydroxy-3-(4-hydroxy-3-methoxy-phenyl)-5,7-dimethoxy-chromen-4-one 
• 175988-53-1 Acetic acid 3-(4-acetoxy-3-methoxy-phenyl)-5-hydroxy-7-methoxy-4-oxo-4H-chromen-6-yl ester 
• 175988-47-3 Acetic acid 3-(4-acetoxy-3-methoxy-phenyl)-5,7-dimethoxy-4-oxo-4H-chromen-6-yl ester 

Relevant academic research and scientific papers

Studies of the selective O-alkylation and dealkylation of flavonoids. XX. A convenient method for synthesizing 5,6,7-trihydroxyisoflavones and 5,6-dihydroxy-7-methoxyisoflavones

3′,6′-Bis(benzyloxy)-2′,4′-dimethoxychalcones, which were derived from dibenzyl ether of 3,6-dihydroxy-2,4-dimethoxyacetophenone, were oxidatively rearranged with thallium(III) nitrate (TTN) in methanol to give 2-aryl-1-[3,6-bis(benzyloxy)-2,4-dimethoxyphenyl]-3,3-dimethoxypropan-1-ones; these products were converted into 6-hydroxy-5,7-dimethoxyisoflavones by hydrogenolysis followed by cyclization. The 5-methoxy group in the acetates of the isoflavones was selectively cleaved with 5% (w/v) anhydrous aluminum bromide in acetonitrile to give quantitatively the corresponding 5-hydroxyisoflavones, which were hydrolyzed to 5,6-dihydroxy-7-methoxyisoflavones. The acetates were also demethylated to 5,6,7-trihydroxyisoflavones with 30% (w/v) anhydrous aluminum chloride in acetonitrile at 70 °C for 36-48 h. The spectral properties of these isoflavones were examined and some natural isoflavones were identified.