6962-57-8

Basic information

• Product Name: 3,6-DIHYDROXY-2,4-DIMETHOXYACETOPHENONE
• Synonyms: 1-(3,6-DIHYDROXY-2,4-DIMETHOXYPHENYL)ETHANONE;3,6-DIHYDROXY-2,4-DIMETHOXYACETOPHENONE
• CAS NO: 6962-57-8
• Molecular Formula: C₁₀H₁₂O₅
• Molecular Weight: 212.2
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 6962-57-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 425.4 °C at 760 mmHg
• Flash Point: 171.2 °C
• Appearance: /
• Density: 1.279 g/cm³
• Vapor Pressure: 7.77E-08mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 3,6-DIHYDROXY-2,4-DIMETHOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-DIHYDROXY-2,4-DIMETHOXYACETOPHENONE(6962-57-8)
• EPA Substance Registry System: 3,6-DIHYDROXY-2,4-DIMETHOXYACETOPHENONE(6962-57-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 6962-57-8(Hazardous Substances Data)

Usage

Preparation

Preparation by Fries rearrangement of 1,4-diacetoxy- 2,6-di-methoxybenzene with aluminium chloride in nitrobenzene at r.t.

InChI:InChI=1/C10H12O5/c1-5(11)8-6(12)4-7(14-2)9(13)10(8)15-3/h4,12-13H,1-3H3

Upstream product

• 7702-17-2 4-(acetyloxy)-3,5-dimethoxyphenyl acetate 
• 64-19-7 acetic acid 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 
• 15233-65-5 2,6-dimethoxy-1,4-hydroquinone 
• 108-24-7 acetic anhydride 
• 530-55-2 2,6-dimethoxy-p-quinone 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 5333-45-9 1,2,3,5-tetramethoxybenzene 
• 75-36-5 acetyl chloride 
• 77-78-1 dimethyl sulfate 
• 21919-63-1 3-acetyl-4-hydroxy-2,6-dimethoxyphenyl acetate 
• 642-71-7 3,4,5-trimethoxyphenol 
• 480-66-0 2,4,6-trihydroxyacetophenone 

Downstream Products

• 18003-33-3 3',4',5,6,7-pentahydroxyflavone 
• 2306-27-6 sinensetin 
• 103777-33-9 1-(3-Butoxy-6-hydroxy-2,4-dimethoxy-phenyl)-ethanone 
• 103777-36-2 1-(6-Hydroxy-2,4-dimethoxy-3-octyloxy-phenyl)-ethanone 
• 103777-40-8 1-(3-Hexadecyloxy-6-hydroxy-2,4-dimethoxy-phenyl)-ethanone 
• 104481-00-7 1-(6-hydroxy-2,4-dimethoxy-3-methoxymethoxyphenyl)-ethanone 
• 22248-14-2 6-hydroxy-2,3,4-trimethoxyacetophenone 
• 34334-69-5 cirsiliol 
• 51145-78-9 2-(3,4-bis-benzyloxy-phenyl)-5,6,7-trimethoxy-chromen-4-one 
• 51145-79-0 3',4'-dihydroxy-5,6,7-trimethoxyflavone 
• 55274-37-8 3'4'-dibenzyloxy-2-hydroxy-4,5,6-trimethoxydibenzoyl methane 
• 55274-36-7 2-(3,4-dibenzyloxybenzoyloxy) 4,5,6-trimethoxy acetophenone 
• 103776-69-8 cirsiliol 5-hexyl ether 
• 102508-37-2 2-(3,4-Dihydroxy-phenyl)-5-hydroxy-7-methoxy-6-pentyloxy-chromen-4-one 

Relevant articles and documents

chromane derivatives, and pharmaceutical composition for preventing or treating neovascular eye disease or cancer containing the same as an active ingredient

The invention relates to compounds of formula 1 which are chroman derivatives. The present invention provides a pharmaceutical composition for treating diseases associated with cancer or neovascularization comprising a hydrate thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. Chemical Formula 1. In Chemical Formula 1 R, R represents a hydrogen atom. 1 R/R2 R/R3 R/R4 R/R5 R/R6 R/R7 As defined in the description of the invention.

Method for preparing baicalein

The invention discloses a method for preparing baicalein. According to the method, 2,6-dimethoxy-p-benzoquinone used as an initial raw material is subjected to reduction, Friedel-Crafts acetylation, claisen condensation, dehydrogenation oxidation cyclization and demethylation five reactions to obtain baicalein with high yield. The method uses low-price and easily-available initial raw material, reagent and the like, has few synthesizing steps, is easy and convenient to operate and easy for production control, has high product yield and high purity, and is suitable for large-scale preparation and production application of baicalein.

A practical and economical high-yielding, six-step sequence synthesis of a flavone: Application to the multigram-scale synthesis of ladanein

Herein we report a short and economic synthesis of the antiviral flavonoid lead ladanein (1). Ladanein is obtained from 2,6-dimethoxyquinone (11) in six steps with 51% overall yield. After a high-yielding reductive acetylation and Fries rearrangement, the