102645-33-0

Basic information

• Product Name: 2,5-DICHLORO-4-FORMYLPYRIDINE
• Synonyms: 2,5-dichloro-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 2,5-dichloro-;2,5-DICHLORO-4-FORMY;2,5-dichloro-3-forMylpyridine-4-carboxylic acid;2,5-dichloropyridine-4-carbaldehyde;2,5-DICHLOROPYRIDINE-4-CARBOXALDEHYDE;2,5-DICHLORO-4-FORMYLPYRIDINE
• CAS NO: 102645-33-0
• Molecular Formula: C₆H₃Cl₂NO
• Molecular Weight: 176
• Product Categories: Pyridine;Pyridines;Boronic Acid;Chlorinated heterocyclic series
• Mol File: 102645-33-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 73-74°
• Boiling Point: 256.3 °C at 760 mmHg
• Flash Point: 108.8 °C
• Appearance: /
• Density: 1.488 g/cm³
• Vapor Pressure: 0.0155mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: -3.62±0.10(Predicted)
• CAS DataBase Reference: 2,5-DICHLORO-4-FORMYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DICHLORO-4-FORMYLPYRIDINE(102645-33-0)
• EPA Substance Registry System: 2,5-DICHLORO-4-FORMYLPYRIDINE(102645-33-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 102645-33-0(Hazardous Substances Data)

Usage

Uses

2,5-Dichloro-4-pyridinecarboxaldehyde, is an intermediate in the preparation of various pharmaceutical compounds. It is used in the synthesis of 2-Amino-5-aryl-pyridines as selective CB2 agonists.

InChI:InChI=1/C6H3Cl2NO/c7-5-2-9-6(8)1-4(5)3-10/h1-3H

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

BENZIMIDAZOLE DERIVATIVES

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1A, R1B, R1C, R2, R3, R4, R5, RA, RB, RC and X are as defined herein. These novel benzimidazole derivatives are useful in therapy, in particular for treating diseases or conditions mediated by SMO, including the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Certain phenoxy-pyridine-carbonitriles having antiviral activity

Substituted pyridines exhibiting antiviral activity are disclosed. Also disclosed are methods of use involving the substituted pyridines as well as compositions comprising a non-toxic, pharmaceutically-acceptable carrier in combination with one or more said substituted pyridines.