1026451-65-9

Upstream product

• 195388-52-4 (R)-1-tert-butyldiphenylsiloxy-1,2-dihydro-naphthalene 
• 123849-23-0 (R)-(+)-1-hydroxy-1,2-dihydronaphthalene 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 124379-29-9 (4S)-4-(3,4-dichlorophenyl)-1-tetralone 
• 167026-40-6 (1R,4S)-4-(3,4-dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-ol 
• 195388-54-6 (R)-4-tert-butyl(4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yloxy)diphenylsilane 
• 195388-56-8 (1S,4S)-1-azido-4-(3,4-dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalene 
• 87857-41-8 norsertraline 
• 195388-55-7 (+)-(1R)-4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-ol 
• 79617-96-2 Sertraline 
• 195388-53-5 (R)-4-bromo-1-tert-butyldiphenylsiloxy-1,2-dihydro-naphthalene 

Relevant academic research and scientific papers

Selective functionalization of 1,2-dihydronaphthalenols leads to a concise, stereoselective synthesis of sertraline

Asymmetric reductive ring opening of oxabenzonorbornadiene provides dihydronaphthalenols in high ee and good yield. Functionality present in this system can be used to elaborate the core towards a number of targets. As an illustration, a concise stereoselective synthesis of the important antidepressant sertraline is described.