87857-41-8Relevant academic research and scientific papers
An expedient total synthesis of cis-(+)-sertraline from D-phenylglycine
Chandrasekhar,Venkat Reddy
, p. 1111 - 1114 (2007/10/03)
An efficient and practical total synthesis of cis-(+)-Sertraline is developed involving intramolecular Friedel-Crafts cyclization of an appropriately tailored D-phenylglycine. (C) 2000 Elsevier Science Ltd.
Selective functionalization of 1,2-dihydronaphthalenols leads to a concise, stereoselective synthesis of sertraline
Lautens, Mark,Rovis, Tomislav
, p. 8967 - 8976 (2007/10/03)
Asymmetric reductive ring opening of oxabenzonorbornadiene provides dihydronaphthalenols in high ee and good yield. Functionality present in this system can be used to elaborate the core towards a number of targets. As an illustration, a concise stereoselective synthesis of the important antidepressant sertraline is described.
