10265-84-6Relevant academic research and scientific papers
Synthesis and evaluation of novel triazolyl quinoline derivatives as potential antileishmanial agents
Upadhyay, Akanksha,Kushwaha, Pragati,Gupta, Sampa,Dodda, Ranga Prasad,Ramalingam, Karthik,Kant, Ruchir,Goyal, Neena,Sashidhara, Koneni V.
, p. 172 - 181 (2018)
The high potential of quinoline containing natural products and their derivatives in medicinal chemistry led us to discover novel series of 25 compounds for the development of new antileishmanial agents. A series of triazolyl 2-methyl-4-phenylquinoline-3-carboxylate derivatives has been synthesized via click chemistry inspired molecular hybridization approach and evaluated against Leishmania donovani. Most of the screened derivatives exhibited significant in vitro anti-leishmanial activity against promastigote (IC50 ranging from 2.43 to 45.75 μM) and intracellular amastigotes (IC50 ranging from 7.06 to 34.9 μM) than the control, miltefosine (IC50 = 8.4 μM), with less cytotoxicity in comparison to the standard drugs. Overall results revealed that prototype signify a new structural lead for antileishmanial chemotherapy.
Friedl?nder annulation: Scope and limitations of metal salt Lewis acid catalysts in selectivity control for the synthesis of functionalised quinolines
Tanwar, Babita,Kumar, Dinesh,Kumar, Asim,Ansari, Md. Imam,Qadri, Mohammad Mohsin,Vaja, Maulikkumar D.,Singh, Madhulika,Chakraborti, Asit K.
supporting information, p. 9824 - 9833 (2015/12/01)
The scope and limitations of metal salt Lewis acid catalysts were examined for the selectivity control for the formation of Friedl?nder and non-Friedl?nder products during the reaction involving 2-aminobenzophenone and ethyl acetoacetate. Among a pool of
Poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) and N,N,N′,N′-tetrabromobenzene-1,3-disulfonamide as efficient reagents for synthesis of quinolines
Ghorbani-Vaghei, Ramin,Akbari-Dadamahaleh, Somayeh
scheme or table, p. 1055 - 1058 (2009/05/11)
Poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) [PBBS] and N,N,N′,N′-tetrabromobenzene-1,3-disulfonamide [TBBDA] were used as efficient reagents for the synthesis of quinolines in excellent yields from 2-aminoaryl ketones and carbonyl compounds under aqueo
Synthesis of 2-hydroxy-1,2,3,4-tetrahydroquinoline derivatives by a cyclocondensation reaction
Cremonesi, Giuseppe,Croce, Piero Dalla,Fontana, Francesco,La Rosa, Concetta
, p. 475 - 480 (2008/02/03)
The reaction of enolates (2) of 1,3-dicarbonyl compounds with N-(2-bromomethylphenyl)benzenesulfonamides (1) gives N-phenylsulfonyl-2-hydroxy-1,2,3,4-tetrahydroquinoline derivatives (3) whose structure and stereochemistry were assigned on the basis of ana
Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling
Anzini,Cappelli,Vomero,Seeber,Menziani,Langer,Hagen,Manzoni,Bourguignon
, p. 1134 - 1150 (2007/10/03)
The synthetic-computational approach to the study of the binding site of peripheral benzodiazepine receptor (PBR) ligands related to 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195, 1) within their receptor (Cappelli et a
