159818-67-4Relevant academic research and scientific papers
A Non-Peptide NK1 Receptor Agonist Showing Subpicomolar Affinity
Cappelli, Andrea,Giuliani, Germano,Mohr, Galla Pericot,Gallelli, Andrea,Anzini, Maurizio,Vomero, Salvatore,Cupello, Aroldo,Scarrone, Simona,Matarrese, Mario,Moresco, Rosa Maria,Fazio, Ferruccio,Finetti, Federica,Morbidelli, Lucia,Ziche, Marina
, p. 1315 - 1318 (2007/10/03)
3-Quinolinecarboxamides have been synthesized and evaluated for their binding to the human NK1 receptor. Several secondary amide derivatives show NK1 receptor affinity in the picomolar range. The most active compound, hydroxymethylca
Condensed heterocyclic compounds, their production and use
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, (2008/06/13)
Novel compound represented by the formula: STR1 such as 6-Chloro-N-(2,6-diethoxyphenyl)-4-(2-methylphenyl-2-oxo-2H-1-benzopyran-3-acetamide: STR2 or a salt thereof. The compound has an excellent activity of inhibiting ACAT, lowering the cholesterol in blood and inhibiting tachykinin receptor. The present invention also relates to the production and use of the disclosed compound.
