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Usage

Uses

Used in Organic Synthesis:
3-Bromo-6-Methylchromone is utilized as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the formation of new chemical bonds and the creation of novel molecules with potential applications in various fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-Bromo-6-Methylchromone is employed as a potential drug candidate for the treatment of various medical conditions. Its molecular structure and properties make it a promising candidate for the development of new therapeutic agents.
Used in Chemical and Biological Studies:
3-Bromo-6-Methylchromone serves as a valuable tool in chemical and biological research. Its unique properties and reactivity enable scientists to explore new reaction pathways, investigate the mechanisms of various biological processes, and develop innovative strategies for drug discovery and development.

Upstream product

• 110-89-4 piperidine 
• 60-29-7 diethyl ether 
• 103030-34-8 2,3-dibromo-6-methyl-chroman-4-one 
• 89807-39-6 1-(2-hydroxy-5-methylphenyl)-3-(N,N-dimethylamino)propenone 
• 107055-51-6 6-methyl-3-piperidino-chroman-4-one 
• 38445-23-7 6-methyl-chromen-4-one 

Downstream Products

• 1429426-05-0 2-(2-hydroxy-5-methylbenzoyl)-4H-furo[3,2-c]chromen-4-one 
• 1429426-07-2 2-(2-hydroxy-5-methylbenzoyl)-8-methyl-4H-furo[3,2-c]chromen-4-one 

Relevant academic research and scientific papers

Synthesis of functionalized 2-salicyloylfurans, furo[3,2-b]chromen-9-ones and 2-benzoyl-8H-thieno[2,3-b]indoles by one-pot cyclizations of 3-halochromones with β-ketoamides and 1,3-dihydroindole-2-thiones

Functionalized 2-salicyloylfurans and 2-benzoyl-8H-thieno[2,3-b]indoles were prepared under mild conditions by reaction of 3-halochromones with β-ketoamides and 1,3-dihydroindole-2-thiones, correspondently. The subsequent oxidative cyclization of the products resulted in formation of the corresponding furo[3,2-b]chromen-9-ones. These molecules could also be directly prepared from 3-halochromones using a one-pot protocol. The cyclization reactions reported herein are mechanistically surprising as they proceed via the oxygen and not via the (more nucleophilic) nitrogen atom of the β-ketoamide. This journal is

Electrochemical C-H Halogenations of Enaminones and Electron-Rich Arenes with Sodium Halide (NaX) as Halogen Source for the Synthesis of 3-Halochromones and Haloarenes

Without employing an external oxidant, the simple synthesis of 3-halochromones and various halogenated electron-rich arenes has been realized with electrode oxidation by employing the simplest sodium halide (NaX, X = Cl, Br, I) as halogen source. This electrochemical method is advantageous for the simple and mild room temperature operation, environmental friendliness as well as broad substrate scope in both C-H bond donor and halogen source components.

Synthesis of 3-halochromones with simple KX halogen sources enabled by: In situ halide oxidation

On the basis of a designated in situ oxidation tactic, the synthesis of 3-halochromones has been realized for the first time by using simple KX (X = Br, I) salts as halogen sources. Instead of the free radical process, the control experiments indicate that the reported reactions proceed through a halogenium intermediate. Compared to the known synthetic methods relying on molecular halogen, haloid acid or N-halosuccinimide as the halogen source, the present method is attractive due to its higher atom economy and being more friendly to the operator, thus providing a practical complimentary approach to the preparation of useful halochromone compounds.

A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5′-nucleotidase inhibitory effects

A new and efficient domino reaction of 3-chlorochromones with electron-rich aminoheterocycles was developed which allows for a convenient synthesis of a variety of pyrazolo[3,4-b]pyridines, pyrrolo[2,3-b]pyridines, pyrido[2,3-d]pyrimidines and benzofuro[3,2-b]pyridines. The products exhibit strong fluorescence. In addition, they exhibit significant ecto-5′-nucleotidase inhibition properties and cytotoxic behavior.