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General Description

2,4-Thiazolidinedione, 3-[(2,4-dichlorophenyl)methyl]- is a chemical compound that belongs to the class of thiazolidinediones, which are used as antidiabetic drugs. It is a derivative of the thiazolidinedione core structure, containing a benzylidene group at the C3 position. 2,4-Thiazolidinedione, 3-[(2,4-dichlorophenyl)methyl]- has been studied for its potential therapeutic effects on diabetes and related conditions, due to its ability to regulate insulin sensitivity and glucose metabolism. It has also been investigated for its potential anti-inflammatory and antioxidant properties. Additionally, its chemical structure and properties make it of interest for further research and development in the field of medicinal chemistry.

Upstream product

• 2295-31-0 thiazoline-2,4-dione 
• 94-99-5 2,4-Dichlorobenzyl chloride 
• 20443-99-6 2,4-dichlorobenzyl bromide 

Downstream Products

• 1213236-04-4 C₁₇H₁₀Cl₃N₅O₂S₃ 

Relevant academic research and scientific papers

Synthesis of Novel Hybrids of Thiazolidinedione-Triazoles as Potential Lipase and α-Glucosidase Inhibiting Agents

Novel thiazolidinedione-triazole analogs (5a-5n, 6) were synthesized and screened for pancreatic lipase and intestinal α-glucosidase inhibitory activity. Analogs with nitro and fluoro benzyl substitutions at thiazolidinedione moiety 5a (IC50 28

Synthesis and antimicrobial activity of novel 5-[(1H-indol-3-yl)methylene]thiazolidine-2,4-dione–[1,2,3]triazole hybrids

5-[(1H-Indol-3-yl)methylene]thiazolidine-2,4-dione–[1,2,3]triazole hybrid derivatives were synthesized by click chemistry reaction and screened for antimicrobial activity against Gram positive and Gram negative bacteria and fungal species. All synthesized

Synthesis and antidiabetic activity of morpholinothiazolyl-2,4- thiazolidindione derivatives

We report the synthesis and the in vitro insulin releasing and glucose uptake activity of the morpholino thiazolyl-2,4-thiazolidinediones (1-15). Compounds 5, 1115 (at lower concentration; 0.001mg/ml) were able to increase insulin release in the presence

Synthesis and antidiabetic activity of some new chromonyl-2,4- thiazolidinediones

A series of chromonyl-2,4-thiazolidinediones (VIa-f) and chromonyl-2,4-imidazolidinediones (VIIa-f) was prepared by Knoevenagel reaction of substituted benzyl-2,4-thiazolidinediones (IVa-f) and substituted benzyl-2,4-imidazolidinediones (Va-f) with chromo

Some new thiazolyl thiazolidinedione derivatives as aldose reductase inhibitors

In diabetes, increased flux through the polyol pathway has been implicated in the development of diabetic complications such as cataract, retinopathy, neuropathy, and nephropathy. Aldose reductase (AR) appears to be the key factor in the reduction of gluc

Synthesis and antidiabetic activity of novel 2,4-thiazolidinedione derivatives containing a thiazole ring

A series of thiazolyl-2,4-thiazolidinediones (Ia-f, IIa-f and IIIa-f ) was prepared by Knoevenagel reaction of substituted benzyl-2,4-thiazolidinediones (4a-f) with chlorothiazolecarbaldehydes (2, 3a-b). The prepared compounds were tested for their insuli