20443-99-6

Basic information

• Product Name: 2,4-Dichlorobenzyl bromide
• Synonyms: 2,4-Dichlorobenzyl bromide;1-(Brommethyl)-2,4-dichlorbenzol
• CAS NO: 20443-99-6
• Molecular Formula: C₇H₅BrCl₂
• Molecular Weight: 239.9246
• Mol File: 20443-99-6.mol
• Article Data: 19

Chemical Properties

• Melting Point: 32 °C
• Boiling Point: 260.852oC at 760 mmHg
• Flash Point: 126.228oC
• Appearance: /
• Density: 1.68g/cm3
• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: 0-10°C
• Solubility: soluble in Methanol
• CAS DataBase Reference: 2,4-Dichlorobenzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichlorobenzyl bromide(20443-99-6)
• EPA Substance Registry System: 2,4-Dichlorobenzyl bromide(20443-99-6)

Safety Data

• RIDADR: 3261
• Hazardous Substances Data: 20443-99-6(Hazardous Substances Data)

Usage

General Description

2,4-Dichlorobenzyl bromide is a chemical compound often used in organic chemistry. As an aryl halide, it's typically employed as a reactive intermediate within different types of chemical synthesis. The compound is identified by the presence of two chlorides and one bromine atom attached to a benzene ring. It's known to be corrosive and can cause severe burns and eye damage, so proper protective measures are required while handling it. While it isn't typically used in day-to-day consumer products, it holds importance in the realm of scientific research and industrial applications. The 2,4-Dichlorobenzyl bromide is a versatile and valuable substance in the field of chemistry despite its potential hazards.

InChI:InChI=1/C7H5BrCl2/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2

Upstream product

• 95-73-8 2,4-dichlorotoluene 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 60211-56-5 2,4-dichlorobenzyl fluoride 
• 50-84-0 2,4 dichlorobenzoic acid 
• 6574-98-7 2,4-dichlorobenzylnitrile 
• 1058649-24-3 2,4-dichloro-1-[(ethoxymethoxy)methyl]benzene 
• 877468-98-9 2,4-dichloro-1-(methoxymethoxy)methyl benzene 
• 1777-82-8 (2,4-dichlorophenyl)methanol 

Downstream Products

• 97753-68-9 (2,4-dichloro-benzyl)-(3-piperidino-propyl)-amine 
• 29516-69-6 2-(2,4-Dichloro-benzyloxy)-1-methyl-3,5-dinitro-benzene 
• 29506-84-1 1-sec-Butyl-2-(2,4-dichloro-benzyloxy)-3,5-dinitro-benzene 
• 29506-76-1 2-(2,4-Dichloro-benzyloxy)-1-isopropyl-3,5-dinitro-benzene 
• 38265-48-4 Dithiophosphoric acid S-(2,4-dichloro-benzyl) ester O-ethyl ester S'-(2-methoxy-ethyl) ester 
• 38265-49-5 Dithiophosphoric acid S-(2,4-dichloro-benzyl) ester S'-(2-ethoxy-ethyl) ester O-ethyl ester 
• 52370-40-8 O-(2,4-dichlorobenzyl)hydroxylamine 
• 1027539-73-6 3-Cyano-4-(2,4-dichloro-benzylsulfanyl)-3-hydroxy-butyric acid methyl ester 
• 919112-62-2 C₂₁H₃₂Cl₂N₂O₃S 
• 113075-86-8 6,8-dichloro-3,4-dihydro-1H-2-naphthalone 
• 6306-60-1 2,4-Dichlorophenylacetonitrile 

Relevant articles and documents

PRMTI Type methyltransferase inhibition active compound as well as preparation and application thereof

The invention relates to a compound with PRMT I-type methyltransferase inhibition activity and preparation and application thereof, wherein the compound has the structure shown I. The compound of the formula I has a good inhibition effect on PRMT I-type m

tBuOK-Promoted Cyclization of Imines with Aryl Halides

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramolecular coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.

Nucleophilic Substitution of Aliphatic Fluorides via Pseudohalide Intermediates

A method for aliphatic fluoride functionalization with a variety of nucleophiles has been reported. Carbon–fluoride bond cleavage is thermodynamically driven by the use of silylated pseudohalides TMS-OMs or TMS-NTf2, resulting in the formation of TMS-F and a trapped aliphatic pseudohalide intermediate. The rate of fluoride/pseudohalide exchange and the stability of this intermediate are such that little rearrangement is observed for terminal fluoride positions in linear aliphatic fluorides. The ability to convert organofluoride positions into pseudohalide groups allows facile nucleophilic attack by a wide range of nucleophiles. The late introduction of the nucleophiles also allows for a wide range of functional-group tolerance in the coupling partners. Selective alkyl fluoride mesylation is observed in the presence of other alkyl halides, allowing for orthogonal synthetic strategies.