1026586-82-2

Upstream product

• 59983-39-0 (S)-1-amino-2-(methoxymethyl)pyrrolidine 
• 65838-17-7 1,3-di-(N-benzylamino)-2-hydroxypropane 
• 100-46-9 benzylamine 
• 245679-89-4 1,3-dibenzyl-1,2,3,4,5,6-hexahydropyrimidine-2,5-dione 
• 245679-88-3 1,3-dibenzyl-1,2,3,4,5,6-hexahydro-5-hydroxypyrimidin-2-one 

Downstream Products

• 245679-92-9 (S)-1,3-Dibenzyl-4-butyl-tetrahydro-pyrimidine-2,5-dione 

Relevant academic research and scientific papers

Asymmetric synthesis of 1,2,3,4,5,6-hexahydro-5-hydroxypyrimidin-2-ones as potential HIV-protease inhibitors

The first asymmetric synthesis of potential cyclic urea HIV protease inhibitors of Type 2 is reported. The synthesis is short and highly versatile in the choice of the substitution pattern and absolute configuration of the products starting from readily available materials. Nonchiral central building block 5 was synthesized and subsequently asymmetrically alkylated under (R)-/(S)-1-amino-2-(methoxymethyl)pyrrolidine (RAMP/SAMP)-auxiliary control to provide 8a-e. The alkylated ketones then were reduced to the target compounds 9a-e, with good-to-excellent overall yields, as well as diastereoisomeric and enantiomeric purities.