1026590-19-1

Basic information

• Product Name: 5-[1-(4-{2-[(5-Chloro-pyridin-2-yl)-methyl-amino]-ethoxy}-phenyl)-meth-(Z)-ylidene]-thiazolidine-2,4-dione
• CAS NO: 1026590-19-1
• Molecular Weight: 389.862
• Mol File: 1026590-19-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[1-(4-{2-[(5-Chloro-pyridin-2-yl)-methyl-amino]-ethoxy}-phenyl)-meth-(Z)-ylidene]-thiazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[1-(4-{2-[(5-Chloro-pyridin-2-yl)-methyl-amino]-ethoxy}-phenyl)-meth-(Z)-ylidene]-thiazolidine-2,4-dione(1026590-19-1)
• EPA Substance Registry System: 5-[1-(4-{2-[(5-Chloro-pyridin-2-yl)-methyl-amino]-ethoxy}-phenyl)-meth-(Z)-ylidene]-thiazolidine-2,4-dione(1026590-19-1)

Safety Data

• Hazardous Substances Data: 1026590-19-1(Hazardous Substances Data)

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 1027659-85-3 2-[(5-Chloro-pyridin-2-yl)-methyl-amino]-ethanol 
• 2295-31-0 thiazoline-2,4-dione 
• 1025966-76-0 4-{2-[(5-Chloro-pyridin-2-yl)-methyl-amino]-ethoxy}-benzaldehyde 

Relevant articles and documents

benzyl>-2,4-thiazolidinediones as Potent Antihyperglycemic Agents

A series of -2,4-thiazolidinediones and benzyl>-2,4-thiazolidinediones was synthesized from the corresponding aldehydes.Compounds from the urea series, exemplified by 16, showed antihyperglycemic potency comparable with known agents of the type such as pioglitazone and troglitazone (CS-045).The benzoxazole 49, a cyclic analogue of 16, was a very potent enhancer of insulin sensitivity, and by modification of the aromatic heterocycle, an aminopyridine, 37, was identified as a lead compound from SAR studies.Evaluation of antihyperglycemic activity together with effects on blood hemoglobin content, to determine the therapeutic index, was performed in 8-day repeat administration studies in genetically obese C57 BI/6 ob/ob mice.From these studies, BRL 49653 (37) has been selected, on the basis of antihyperglycemic potency combined with enhanced selectivity against reductions in blood hemoglobin content, for further evaluation.