1026689-58-6

Basic information

• Product Name: benzyl 6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate
• Synonyms: benzyl 6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate
• CAS NO: 1026689-58-6
• Molecular Weight: 257.292
• Mol File: 1026689-58-6.mol

Chemical Properties

• CAS DataBase Reference: benzyl 6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate(1026689-58-6)
• EPA Substance Registry System: benzyl 6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate(1026689-58-6)

Safety Data

• Hazardous Substances Data: 1026689-58-6(Hazardous Substances Data)

Upstream product

• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 62002-31-7 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine dihydrochloride 
• 6882-74-2 4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 87673-88-9 1-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 
• 64403-25-4 3-methyl-3,4,6,7-tetrahydro-5H-imidazo<4,5-c>pyridine 

Relevant articles and documents

COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN

Provided herein are certain compounds of formula (I) and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.

UR-DEBa176: A 2,4-Diaminopyrimidine-Type Radioligand Enabling Binding Studies at the Human, Mouse, and Rat Histamine H4 Receptors

Differences in sequence homology between human (h), mouse (m), and rat (r) histamine H4 receptors (H4R) cause discrepancies regarding affinities, potencies, and/or efficacies of ligands and therefore compromise translational animal models and the applicability of radioligands. Aiming at a radioligand enabling robust and comparative binding studies at the h/m/rH4Rs, 2,4-diaminopyrimidines were synthesized and pharmacologically investigated. The most notable compounds identified were two (partial) agonists with comparable potencies at the h/m/rH4Rs: UR-DEBa148 (N-neopentyl-4-(1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)pyrimidin-2-amine bis(2,2,2-trifluoroacetate), 43), the most potent [pEC50 (reporter gene assay) = 9.9/9.6/10.3] compound in the series being slightly G-protein biased and UR-DEBa176 [(R)-4-[3-(dimethylamino)pyrrolidin-1-yl]-N-neopentylpyrimidin-2-amine bis(2,2,2-trifluoroacetate), 46, pEC50 (reporter gene assay) = 8.7/9.0/9.2], a potential "cold" form of a tritiated H4R ligand. After radiolabeling, binding studies with [3H]UR-DEBa176 ([3H]46) at the h/m/rH4Rs revealed comparable Kd values (41/17/22 nM), low nonspecific binding (11-17%, aKd), and fast associations/dissociations (25-30 min) and disclosed [3H]UR-DEBa176 as useful molecular tool to determine h/m/rH4R binding affinities for H4R ligands.

DERIVATIVES OF N- [(1H-PYRAZOL-1-YL) ARYL] - 1H - INDOLE OR 1H - INDAZOLE - 3 - CARBOXAMIDE, THEIR PREPARATION AND THEIR USE AS P2Y12 ANTAGONISTS

The present invention relates to compounds corresponding to formula (I) and their use as P2Y12 antagonists for the treatment of cardiovascular diseases.

Anti-ulcer and antisecretory activity of selected imidazopiperidines

New thioureas and ureas with an interesting anti-ulcer and antisecretory activity are presented. The chemical synthesis, determination of the structure, and structure-activity relationships of the compounds are discussed.