1026700-82-2Relevant academic research and scientific papers
Anti-inflammatory and analgesic activities of newly synthesized chiral peptide derivatives using (3-benzoyl-4,5-dioxo-2-phenyl-pyrrolidin-1-yl)acetic acid ethylester as starting material
Fakhr, Issa M.,Amr, Abdel-Galil E.,Sabry, Nermien M.,Abdalah, Mohamed M.
experimental part, p. 174 - 180 (2009/04/06)
A series of heterocyclic derivatives was synthesized using (3-benzoyl-4,5-dioxo-2-phenyl-pyrrolidin-1-yl)acetic acid ethyl ester 1 as starting material. Treatment of 1 with 1 N NaOH or hydrazine hydrate afford the corresponding acid 2 and acid hydrazides 4 and 5, which were reacted with several reagents to produce some new peptido hetero-organic derivatives 6-12. The pharmacological screening showed that many of these newly synthesized compounds have good antiinflammatory and analgesic activities comparable to diclofenac potassium and valdecoxib as reference drugs.
