1026700-75-3

Upstream product

• 1026700-68-4 (3-benzoyl-4,5-dioxo-2-phenyl-pyrrolidin-1-yl)acetic acid ethyl ester 

Downstream Products

• 1026700-82-2 N-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-{3-[(1,3-dioxo-1,3-dihydro-isoindol-2-ylimino)-phenylmethyl]-4,5-dioxo-2-phenyl-pyrrolidin-1-yl}-acetamide 
• 1026700-81-1 (3-(ethylthiosemihydrazino-phenylmethyl)-4,5-dioxo-2-phenyl-pyrrolidin-1-yl)-acetic acid N'-thiopropionyl hydrazine 
• 1026700-86-6 2-{2,3-dioxo-5-phenyl-4-[phenyl-(4,5,6,7-tetrachloro-1,3-dioxo-1,3-dihydro-isoindol-2-ylimino)-methyl]pyrrolidin-1-yl}-N-(4,5,6,7-tetrachloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide 
• 1026700-93-5 (3-{[(4-methylbenzylidene)hydrazono]-phenylmethyl}-4,5-dioxo-2-phenyl-pyrrolidin-1-yl)-acetic acid (4-methylbenzylidine)-hydrazide 
• 1026700-92-4 (3-{[(4-fluorobenzylidene)hydrazono]-phenylmethyl}-4,5-dioxo-2-phenyl-pyrrolidin-1-yl)-acetic acid (4-fluorobenzylidine)-hydrazide 

Relevant academic research and scientific papers

Anti-inflammatory and analgesic activities of newly synthesized chiral peptide derivatives using (3-benzoyl-4,5-dioxo-2-phenyl-pyrrolidin-1-yl)acetic acid ethylester as starting material

A series of heterocyclic derivatives was synthesized using (3-benzoyl-4,5-dioxo-2-phenyl-pyrrolidin-1-yl)acetic acid ethyl ester 1 as starting material. Treatment of 1 with 1 N NaOH or hydrazine hydrate afford the corresponding acid 2 and acid hydrazides 4 and 5, which were reacted with several reagents to produce some new peptido hetero-organic derivatives 6-12. The pharmacological screening showed that many of these newly synthesized compounds have good antiinflammatory and analgesic activities comparable to diclofenac potassium and valdecoxib as reference drugs.