1026716-79-9

Basic information

• Product Name: (2-Dimethylamino-1,6-dihydro-1,3,5,6-tetraaza-cyclopenta[c]fluoren-4-yl)-(4-methoxymethoxy-phenyl)-methanone
• CAS NO: 1026716-79-9
• Molecular Weight: 415.451
• Mol File: 1026716-79-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-Dimethylamino-1,6-dihydro-1,3,5,6-tetraaza-cyclopenta[c]fluoren-4-yl)-(4-methoxymethoxy-phenyl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Dimethylamino-1,6-dihydro-1,3,5,6-tetraaza-cyclopenta[c]fluoren-4-yl)-(4-methoxymethoxy-phenyl)-methanone(1026716-79-9)
• EPA Substance Registry System: (2-Dimethylamino-1,6-dihydro-1,3,5,6-tetraaza-cyclopenta[c]fluoren-4-yl)-(4-methoxymethoxy-phenyl)-methanone(1026716-79-9)

Safety Data

• Hazardous Substances Data: 1026716-79-9(Hazardous Substances Data)

Upstream product

• 162662-26-2 11-(Dimethylamino)-2-<(trifluoromethanesulfonyl)oxy>-12-<<2'-(trimethylsilyl)ethoxy>methyl>-9H-imidazo<4',5':3,4>pyrido<2,3-b>indole 
• 162662-23-9 Ethyl 3-<2-(dimethylamino)-1-<<2'-(trimethylsilyl)ethoxy>methyl>imidazol-5-yl>indole-2-carboxylate 
• 162662-25-1 11-(Dimethylamino)-2-hydroxy-12-<<2'-(trimethylsilyl)ethoxy>methyl>-9H-imidazo<4',5':3,4>pyrido<2,3-b>indole 
• 169902-93-6 3-<2-(Dimethylamino)-1-<<2'-(trimethylsilyl)ethoxy>methyl>imidazol-5-yl>indole-2-carboxylic acid 
• 162662-24-0 3-<2-(Dimethylamino)-1-<<2'-(trimethylsilyl)ethoxy>methyl>imidazol-5-yl>-2-isocyanatoindole 
• 117637-79-3 ethyl 3-iodo-1H-indole-2-carboxylate 
• 106-41-2 4-bromo-phenol 
• 25458-45-1 p-methoxymethoxybromobenzene 
• 169902-92-5 11-(Dimethylamino)-2-(methoxycarbonyl)-9H-imidazo<4',5':3,4>pyrido<2,3-b>indole 

Relevant articles and documents

Total Synthesis of Grossularines-1 and -2

The first total syntheses of grossularines-1 (1a) and -2 (1b) have been completed.The cross-coupling reaction between ethyl 3-iodoindole-2-carboxylate (6) and the directed metalation-derived imidazole 9b gave the ethyl 3-(5-imidazolyl)indole-2-carboxylate 11b.Hydrolysis of the ester group of 11b, followed by Curtius rearrangement, yielded the 2-isocyanatoindole 13b.The thermal electrocyclic reaction of 13b was carried out to provide the desired tetracyclic pyridoindole ring system 14b, which was converted into the triflate 15b.The three-component cross-coupling reaction of the triflate 15b, carbon monoxide, and p-(OMOM)phenylboronic acid (17) followed by hydrolysis gave glossularine-2 (1b) in low yield.In addition, the palladium-catalyzed carbonylation of the triflate 15b afforded the N-deprotected methyl ester 19a or the methyl ester 19b depending on the amounts of triethylamine used.Compound 19a was treated with either p-(OMOM)phenyllithium or 3-(N-TIPS)indolyllithium to obtain grossularine-2 (1b) and grossularine-1 (1a) (37percent), respectively.By contrast, when 19b was treated with the same aryllithium reagents, grossularine-2 (1b) (51percent) and grossularine-1 (1a) (63percent) were produced, respectively.