1026729-08-7

Basic information

• Product Name: 1-bromo-5-(bromomethyl)-2,3-dimethoxybenzene
• Synonyms: 1-bromo-5-(bromomethyl)-2,3-dimethoxybenzene
• CAS NO: 1026729-08-7
• Molecular Weight: 309.985
• Mol File: 1026729-08-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-bromo-5-(bromomethyl)-2,3-dimethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-5-(bromomethyl)-2,3-dimethoxybenzene(1026729-08-7)
• EPA Substance Registry System: 1-bromo-5-(bromomethyl)-2,3-dimethoxybenzene(1026729-08-7)

Safety Data

• Hazardous Substances Data: 1026729-08-7(Hazardous Substances Data)

Upstream product

• 6948-30-7 5-bromoveratralaldehyde 
• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 
• 121-33-5 vanillin 
• 52783-74-1 (3-bromo-4,5-dimethoxyphenyl)methanol 

Downstream Products

• 1238891-84-3 2,3-dibromo-1-(2'-bromo-6'-bromomethyl-3',4'-dimethoxybenzyl)-4,5-dimethoxybenzene 
• 68278-85-3 3-bromo-4,5-dimethoxy-toluene 
• 1623785-62-5 (±)-2-(3′-bromo-4′,5′-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline 
• 1623785-56-7 (±)-2-(3-bromo-4,5-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1623785-58-9 2-(3′-bromo-4′,5′-dimethoxybenzyl)-7-methoxy-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline 
• 1623785-52-3 2-(3′-bromo-4′,5′-dimethoxybenzyl)-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 1623785-68-1 2-(3-bromo-4,5-dimethoxybenzyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline 
• 1623785-50-1 (±)-2-(3-bromo-4,5-dimethoxybenzyl)-7-methoxy-3-methyl-6-(triisopropylsilyloxy)-1,2,3,4-tetrahydroisoquinoline 
• 1623785-46-5 2-(3-bromo-4,5-dimethoxybenzyl)-7-methoxy-6-(triisopropylsilyloxy)-1,2,3,4-tetrahydroisoquinoline 
• 1623785-64-7 2-(3-bromo-4,5-dimethoxybenzyl)-7-ethyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Deconjugative α-Alkylation of Cyclohexenecarboxaldehydes: An Access to Diverse Terpenoids

A general and efficient method for the deconjugative α-alkylation of α,β-unsaturated aldehydes promoted by a synergistic effect between tBuOK and NaH, which considerably increases the reaction rate under mild conditions, is reported. The β,γ-unsaturated aldehyde, resulting from the α-alkylation, is transformed in high yield into the corresponding allyl acetate via a lead(IV) acetate-mediated oxidative fragmentation. This strategy could be used for the construction of the carbon skeleton of a wide variety of alkyl or arylterpenoids.

Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors

A series of novel pyrimidinedione derivatives were designed and evaluated for in vitro dipeptidyl peptidase-4 (DPP-4) inhibitory activity and in vivo anti-hyperglycemic efficacy. Among them, the representative compounds 11, 15 and 16 showed excellent inhibitory activity of DPP-4 with IC50 values of 64.47 nM, 188.7 nM and 65.36 nM, respectively. Further studies revealed that compound 11 was potent in vivo hypoglycemic effect. The structure–activity relationships of these pyrimidinedione derivatives had been discussed, which would be useful for developing novel DPP-4 inhibitors as treating type 2 diabetes.

Total synthesis of the biologically active, naturally occurring 3,4-dibromo-5-[2-bromo-3,4-dihydroxy-6-(methoxymethyl)benzyl]benzene-1,2-diol and regioselective O-demethylation of aryl methyl ethers

3,4-Dibromo-5-[2-bromo-3,4-dihydroxy-6-(methoxymethyl)benzyl]benzene-1, 2-diol (2), a natural product, has been synthesized for the first time starting from (3-bromo-4,5-dimethoxyphenyl)methanol (5) in five steps and with an overall yield of 34%. The reaction of some methoxymethyl-substituted aryl methyl ethers with BBr3, followed by the addition of MeOH, afforded the corresponding methoxymethyl-substituted arylphenols in high yields.