1026778-41-5

Basic information

• Product Name: Aripiprazole hydrochloride
• Synonyms: Aripiprazole hydrochloride
• CAS NO: 1026778-41-5
• Molecular Formula: C23H28Cl3N3O2
• Molecular Weight: 484.853
• EINECS: -0
• Mol File: 1026778-41-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Aripiprazole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Aripiprazole hydrochloride(1026778-41-5)
• EPA Substance Registry System: Aripiprazole hydrochloride(1026778-41-5)

Safety Data

• Hazardous Substances Data: 1026778-41-5(Hazardous Substances Data)

Upstream product

• 129722-25-4 OPC 14857 
• 7647-01-0 hydrogenchloride 
• 129722-12-9 aripiprazole 

Downstream Products

• 129722-12-9 aripiprazole 

Relevant articles and documents

Adaptability of aripiprazole towards forming isostructural hydrogen bonding networks in multi-component salts: A rare case of strong O-H...O - ? weak C-H...O mimicry

Aripiprazole is complexed with benzoic acid (I), 2,4-dihydroxybenzoic acid (II), 2,5-dihydroxybenzoic acid (III), hydrochloric acid (IV) and salicylic acid (V). The resulting salts are characterized by single crystal X-ray diffraction, powder X-ray diffraction, infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. Two salts from the Cambridge Structural Database (aripiprazole nitrate and perchlorate) are included for structural comparison. Interestingly, aripiprazole forms two types of isostructural crystals with the modulation of its conformation and hydrogen bond synthons. Salts with aromatic acids engage in three-dimensional isostructural helical networks and the inorganic acid salts form two-dimensional layered networks. Remarkably, the helices mediated by strong charge assisted O-H...O- interactions are mimicked by weaker neutral C-H...O interactions in aromatic salts of aripiprazole. Our results suggest the isostructurality may be more common in multi-component systems. The salts are stable and can be potential alternatives for suitable formulation of aripiprazole. The Royal Society of Chemistry 2013.

3,4-DIHYDRO-2 (1H) - QUINOLINONE AND 2 (1H)-QUINOLINONE DERIVATIVES

The present invention relates to novel 3,4-dihydro-2(lH)-quinolinone and 2(lH)-quinolinone derivatives, their acceptable acid addition salts, solvates, hydrates and polymorphs thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by atypical antipsychotic agents. The invention further provides methods for using a compound of this invention to determine concentrations of a corresponding 3,4-dihydro-2(lH)- quinolinone or 2(lH)-quinolinone compound, particularly in biological fluids, and to determine metabolism patterns of that 3,4-dihydro-2(lH)-quinolinone or 2(1H)-quinolinone compound.

CARBOSTYRIL DERIVATIVES

A novel carbostyril derivative and salt thereof represented by the formula (1) STR1 (wherein R is a group of the formula STR2 ((wherein R. sup.1 is a C 1-C 3 alkoxy group)), a group of the formula STR3 ((wherein R 2 and R 3 are each, at the same time, a chlorine atom, a bromine atom; and R 4 is a hydrogen atom or a chlorine atom)), 2-methyl-3-nitrophenyl group, 3,5-dichlorophenyl group, or a group of the formula STR4 ((wherein R 5 is a chlorine atom or a bromine atom; and R 6 is a methyl group)); the carbon-carbon bond between 3-and 4-position in the carbostyril skeleton is a single or double bond).