1303607-17-1

Basic information

• Product Name: C₄₆H₅₂Cl₂N₂O₁₂
• CAS NO: 1303607-17-1
• Molecular Weight: 895.831
• Mol File: 1303607-17-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₆H₅₂Cl₂N₂O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₆H₅₂Cl₂N₂O₁₂(1303607-17-1)
• EPA Substance Registry System: C₄₆H₅₂Cl₂N₂O₁₂(1303607-17-1)

Safety Data

• Hazardous Substances Data: 1303607-17-1(Hazardous Substances Data)

Upstream product

• 199177-26-9 3-bromo-5-hydroxybenzaldehyde 
• 13949-93-4 (+/-)-ethyl trans-2-formyl-1-cyclopropanecarboxylate 
• 626-41-5 3,5-dibromophenol 
• 1026787-16-5 tert-butyl (3R,4S)-3-{[[3-hydroxy-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate 
• 1303607-08-0 C₄₇H₆₀Cl₂N₂O₉ 
• 1026787-15-4 tert-butyl (3R,4S)-3-({[3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-(3-methoxypropyl)benzyl](cyclopropyl)amino}carbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate 
• 921630-48-0 [(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{3-methoxypropyl}benzyl)amino]cyclopropane 
• 1026786-89-9 [(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{(1E)-3-methoxyprop-1-en-1-yl}benzyl)amino]cyclopropane 
• 1026786-87-7 3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde 
• 1026786-84-4 3-hydroxy-5-[(1E)-3-(methyloxy)-1-propen-1-yl]benzaldehyde 
• 109716-55-4 ethyl (1S,2S)-2-(hydroxymethyl)cyclopropane-1-carboxylate 
• 1087347-12-3 (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylic acid 
• 173604-87-0 (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate 
• 1087347-11-2 ethyl (1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylate 

Relevant articles and documents

The discovery and synthesis of potent zwitterionic inhibitors of renin

The incorporation of a carboxylic acid within in a series of 3-amido-4-aryl substituted piperidines (represented by general structure 32) led to the discovery of potent, zwitterionic, renin inhibitors with improved off-target profiles (CYP3A4 time-dependent inhibition and hERG affinity) relative to analogous non-zwitterionic inhibitors of the past (i.e., 3). Strategies to address the oral absorption of these zwitterions are also discussed within.