1026920-55-7

Basic information

• Product Name: 4-{4-[(R)-2-(1H-Indol-3-yl)-1-methoxycarbonyl-ethylsulfamoyl]-phenylethynyl}-benzoic acid
• Synonyms: 4-{4-[(R)-2-(1H-Indol-3-yl)-1-methoxycarbonyl-ethylsulfamoyl]-phenylethynyl}-benzoic acid
• CAS NO: 1026920-55-7
• Molecular Weight: 502.547
• Mol File: 1026920-55-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{4-[(R)-2-(1H-Indol-3-yl)-1-methoxycarbonyl-ethylsulfamoyl]-phenylethynyl}-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{4-[(R)-2-(1H-Indol-3-yl)-1-methoxycarbonyl-ethylsulfamoyl]-phenylethynyl}-benzoic acid(1026920-55-7)
• EPA Substance Registry System: 4-{4-[(R)-2-(1H-Indol-3-yl)-1-methoxycarbonyl-ethylsulfamoyl]-phenylethynyl}-benzoic acid(1026920-55-7)

Safety Data

• Hazardous Substances Data: 1026920-55-7(Hazardous Substances Data)

Upstream product

• 98-61-3 p-Iodobenzenesulfonyl chloride 
• 10602-00-3 4-Ethynyl-benzoic acid 
• 203639-53-6 (R)-3-(1H-Indol-3-yl)-2-(4-iodo-benzenesulfonylamino)-propionic acid methyl ester 

Relevant articles and documents

Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives

Various N-sulfonylamino acid derivatives were synthesized and evaluated for their in vitro and in vivo activities to inhibit type IV collagenase (MMP-9 and MMP-2). When the amino acid residue and the sulfonamide moiety were modified, their inhibitory activities were greatly affected by the structure of the sulfonamide moiety. A series of aryl sulfonamide derivatives containing biaryl, tetrazole, amide, and triple bond were found to be potent and highly selective inhibitors of MMP-9 and MMP-2. In addition, these compounds were orally active in animal models of tumor growth and metastasis. These results revealed the potential of the N-sulfonylamino acid derivatives as a new type of candidate drug for the treatment of cancer.