1027101-98-9Relevant academic research and scientific papers
Perthamides C-F, potent human antipsoriatic cyclopeptides
Festa, Carmen,De Marino, Simona,Sepe, Valentina,D'Auria, Maria Valeria,Bifulco, Giuseppe,Andrés, Rosa,Terencio, Maria Carmen,Payá, Miguel,Debitus, Cécile,Zampella, Angela
, p. 7780 - 7786 (2011)
Two new cyclopeptides, perthamides E and F were isolated from the polar extracts of the sponge Theonella swinhoei. The new structures, featuring an unprecedented β-amino acid unit (AHMOA), were determined by interpretation of NMR and MS data. The absolute
Concise, stereoselective route to the four diastereoisomers of 4-methylproline
Murphy, Annabel C.,Mitova, Maya I.,Blunt, John W.,Munro, Murray H.G.
experimental part, p. 806 - 809 (2009/04/07)
The full stereochemical characterization of 4-methylproline, a rare amino acid found in a number of peptidic secondary metabolites, has often been hindered by long reaction sequences or low stereoselectivity in the synthesis leading to reference samples. The preparation of the four diastereoisomers of 4-methylproline by a concise and stereoselective route is presented and features a six-step route with late-stage stereodivergence, good stereoselectivity for both cis- and trans-series (75% and 88% de, respectively), and good overall yields (cumulative yields of 30-40%). Additional data on the Marfey's derivatives of the stereoisomers are also presented.
