201481-62-1

Usage

Uses

Used in Pharmaceutical Industry:
(2S,4S)-4-methylpyrrolidine-2-carboxylic acid hydrochloride is used as a chiral building block for the synthesis of pharmaceuticals and agrochemicals. Its unique stereochemistry allows for the creation of enantiomeric pure drugs, which are essential for the development of effective and safe medications.
Used in Agrochemical Industry:
(2S,4S)-4-methylpyrrolidine-2-carboxylic acid hydrochloride is also utilized in the production of enantiomeric pure agrochemicals, which are important for the development of effective and environmentally friendly pesticides and other agricultural products.

Upstream product

• 1027101-89-8 N-CBz-trans-4-methyl-L-proline ethyl ester 
• 745769-71-5 cis-4-methyl-L-proline ethyl ester 
• 144345-38-0 (2S,4S)-di-tert-butyl 4-methyl-5-oxopyrrolidine-1,2-dicarboxylate 
• 159415-73-3 tert-butyl (2S,4S)-N-tert-butoxycarbonyl-4-methylprolinate 

Downstream Products

• 1027101-98-9 C₁₅H₁₉N₅O₇ 

Relevant academic research and scientific papers

1-[1-(BENZOYL)-PYRROLIDINE-2-CARBONYL]-PYRROLIDINE-2-CARBONITRILE DERIVATIVES

The present invention relates to 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives having pharmacological activity formula (I) to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of a cognitive disorder.

1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives

The present invention relates to 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives having pharmacological activity to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of a cognitive disorder.

Concise, stereoselective route to the four diastereoisomers of 4-methylproline

The full stereochemical characterization of 4-methylproline, a rare amino acid found in a number of peptidic secondary metabolites, has often been hindered by long reaction sequences or low stereoselectivity in the synthesis leading to reference samples. The preparation of the four diastereoisomers of 4-methylproline by a concise and stereoselective route is presented and features a six-step route with late-stage stereodivergence, good stereoselectivity for both cis- and trans-series (75% and 88% de, respectively), and good overall yields (cumulative yields of 30-40%). Additional data on the Marfey's derivatives of the stereoisomers are also presented.

Stereospecific synthesis of naturally-occurring 4-alkylideneglutamic acids, 4-alkylglutamates and 4-alkylprolines

The enaminone 4, prepared from (2S)-pyroglutamic acid, has been found to react in an apparent 1,4-manner with DIBAL and Grignard reagents to afford a variety of alkylidene derivatives 8 which, except for the vinyl derivatives 8e, are formed only as the (E

Stereospecific Synthesis of 4-Alkylglutamates and 4-Alkylprolines

Catalytic reduction of the 4-alkylidenepyroglutamate derivatives (3) affords an effective route to (2S,4S)-4-alkylglutamic acids and (2S,4S)-4-alkylprolines.The route has also been used to prepare a 4-alkylpyroglutamic acid derivative which is stereospeci