1027137-63-8

Upstream product

• 936710-70-2 (4S,5S)-N-Boc-5-(carbethoxymethyl)-2,2-dimethyl-4-(2-methylpropyl)-1,3-oxazolidine 
• 63096-02-6 N-tert-butoxycarbonyl-L-leucine methyl ester 
• 67010-43-9 (3S,4S)-ethyl 4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoate 
• 58521-45-2 tert-butoxycarbonyl-L-leucinal 
• 82010-31-9 (S)-(1-hydroxymethyl-3-methylbutyl)carbamic acid tert-butyl ester 
• 133743-73-4 (S)-5-tert-Butoxycarbonylamino-4-hydroxy-7-methyl-octanoic acid ethyl ester 
• 937799-87-6 [(2R,4S,5S)-5-(N-Boc-amino)-4-hydroxy-2,7-dimethyloctanoyl] N'-isobutyl amide 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 271601-65-1 (2R,4S,5S)-5-[(tert-butyloxycarbonyl)amino]-4-[(tert-butyldimethylsilyl)oxy]-2,7-dimethyloctanoic acid 
• 881009-00-3 (2R,4S,5S)-5-tert-Butoxycarbonylamino-4-hydroxy-2,7-dimethyl-octanoic acid 
• 203806-74-0 (4S,5S)-5-(2-Carboxy-ethyl)-4-isobutyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 169057-47-0 (3R,5S,1'S)-5-[1'-[(tert-butyloxycarbonyl)amino]-3'-methylbutyl]-3-methyldihydrofuran-2(3H)-one 
• 440325-90-6 ethyl (5S)-5-[(tert-butoxycarbonyl)amino]-4-hydroxy-7-methyloct-2-ynoate 
• 105018-81-3 (5S,1'S)-5-<1'--3'-methylbutyl>dihydrofuran-2(3H)-one 

Downstream Products

• 1173887-62-1 C₃₁H₄₃N₃O₆ 
• 1227248-53-4 C₃₃H₅₆N₄O₆ 
• 1227248-54-5 C₃₄H₅₈N₄O₆ 
• 1227248-52-3 C₃₄H₅₈N₄O₆ 
• 1173887-64-3 C₃₀H₄₁Cl₂N₃O₄ 
• 1173887-61-0 C₃₄H₄₅N₃O₄ 
• 1173887-63-2 C₃₀H₄₁N₅O₈ 
• 1173887-60-9 C₃₂H₄₇N₃O₆ 
• 1173887-57-4 C₃₀H₄₃N₃O₄ 
• 1173887-65-4 C₃₀H₄₂ClN₃O₄ 
• 1173887-58-5 C₃₀H₄₂N₄O₆ 

Relevant academic research and scientific papers

Synthesis of β-secretase inhibitors containing a hydroxyethylene dipeptide isostere

β-Secretase inhibitors with a Leu* Ala hydroxyethylene dipeptide (HED) isostere have been an especially interesting topic in recent years. In this study, a template compound 17 was synthesized, featuring truncation at the P2′ position and changes at P2 an

Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase

Based on the structure of OM99-2 and the X-ray crystal structure of its complex with β-secretase, a series of compounds containing the Leu*Ala hydroxyethylene isostere as a scissile bond substitution were designed. 31 compounds were synthesized and their