102714-43-2

Upstream product

• 111220-78-1 methyl 2-(p-chlorophenylsulphinyl)-3-hexanethyleneimino-3-phenylpropanoate 
• 102714-50-1 methyl 2-(p-chlorophenylsulphinyl)-3-phenyl-3-piperidinopropanoate 
• 111220-77-0 methyl 2-(p-chlorophenylsulphinyl)-3-(3-methylpiperidino)-3-phenylpropanoate 
• 111220-80-5 methyl 2-(p-chlorophenylsulphinyl)-4-methyl-3-(2-methylpiperidino)pentanoate 
• 111220-81-6 methyl 2-(p-chlorophenylsulphinyl)-4-methyl-3-(4-methylpiperidino)pentanoate 
• 102714-51-2 methyl 2-(p-chlorophenylsulphinyl)-3-(2-methylpiperidino)-3-phenylpropanoate 
• 102714-52-3 methyl 2-(p-chlorophenylsulphinyl)-4-methyl-3-piperidinopentanoate 
• 102714-49-8 methyl 2-(p-chlorophenylsulphinyl)-3-phenyl-3-pyrrolidinopropanoate 
• 73281-90-0 methyl 4-chlorophenylsulfinylacetate 
• 123-72-8 butyraldehyde 

Relevant academic research and scientific papers

Stereochemistry in the Knoevenagel Reaction of Methyl Arylsulphinylacetate and Aldehydes

The stereochemistry of the mechanism of the amine-catalyzed Knoevenagel reaction has been studied.Simple treatment of methyl arylsulphinylacetate (1) and aldehydes (2) with a catalytic amount of a secondary amine produced thermodynamically stable E-alkene

STEREOCHEMISTRY OF AMINE-CATALYZED KNOEVENAGEL REACTIONS

The amine-catalyzed Knoevenagel reactions of aldehydes and active methylene compounds containing two activating groups were found to involve many reversible steps, and the diastereomeric intermediary condensation compounds yielded thermodynamically stable products via carbanionic intermediates stablized and sterically affected by two activating groups.