1027148-08-8Relevant academic research and scientific papers
Agents for the treatment of overactive detrusor. V. Synthesis and inhibitory activity on detrusor contraction of N-tert-butyl-4,4-diphenyl-2- cyclopentenylamine
Take, Kazuhiko,Okumura, Kazuo,Tsubaki, Kazunori,Taniguchi, Kiyoshi,Terai, Takao,Shiokawa, Youichi
, p. 1858 - 1864 (2007/10/03)
N-tert-Butyl-4,4-diphenyl-2-cyclopentenylamine ((±)-3) was designed to restrict the conformation of terodiline I and was synthesized in a 6-step approach starting with diphenylacetaldehyde (10) or in a 4-step approach starting with 2,2-diphenyl-4-pentenoi
Agents for the treatment of overactive detrusor. VIII. Synthesis and pharmacological properties of 4,4-diphenyl-2-cycloalkenylamines including FK584 and 3,3- or 4,4-diphenylcycloalkylamines
Taniguchi,Okumura,Take,Tsubaki,Terai,Nakanishi,Shiokawa
, p. 71 - 77 (2007/10/02)
This article describes the synthesis of 4,4-diphenyl-2-cycloalkenylamines (3, 5a) including PK584 (S(-)-3a) and 3,3- or 4,4-diphenylcycloalkylamines (2, 4, 5b), and their inhibitory activities against detrusor contraction. The order of inhibitory activity
