1027165-38-3Relevant academic research and scientific papers
Design and synthesis of α-aryloxyphenylacetic acid derivatives: A novel class of PPARα/γ dual agonists with potent antihyperglycemic and lipid modulating activity
Shi, Guo Q.,Dropinski, James F.,McKeever, Brian M.,Xu, Shihua,Becker, Joseph W.,Berger, Joel P.,MacNaul, Karen L.,Eibrecht, Alex,Zhou, Gaochao,Doebber, Thomas W.,Wang, Peiran,Chao, Yu-Sheng,Forrest, Mike,Heck, James V.,Moller, David E.,Jones, A. Brian
, p. 4457 - 4468 (2007/10/03)
The synthesis and structure-activity relationships of novel series of α-aryloxyphenylacetic acids as PPARα/γ dual agonists are reported. The initial search for surrogates of the ester group in the screen lead led first to the optimization of a subseries w
